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  • Lupu, DianaUppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.;Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Toxicol, Cluj Napoca 400012, Romania. (author)

The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-06-01
  • MDPI,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kau-79211
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-79211URI
  • https://doi.org/10.3390/ijms21113978DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173602URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420034URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144060110URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Special issue: Advances in the Research of Endocrine Disrupting Chemicals 2.0
  • Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Andersson, Patrik L.Umeå universitet,Kemiska institutionen,Umeå University,Umea Univ, Fac Sci & Technol, S-90187 Umea, Sweden.(Swepub:umu)paan0001 (author)
  • Bornehag, Carl-Gustav,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Karlstad Univ, Dept Hlth Sci, S-65188 Karlstad, Sweden.(Swepub:kau)caguborn (author)
  • Demeneix, BarbaraCNRS, Evolut Endocrine Regulat UMR 7221, F-75005 Paris, France. (author)
  • Fritsche, EllenIUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany. (author)
  • Gennings, ChrisIcahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA. (author)
  • Lichtensteiger, WalterGREEN Tox GmbH, CH-8057 Zurich, Switzerland. (author)
  • Leist, MarcelUniv Konstanz, In Vitro Toxicol & Biomed, D-78457 Constance, Germany. (author)
  • Leonards, Pim E. G.Vrije University, NLD,Vrije Univ, Dept Environm & Hlth, NL-1081 HV Amsterdam, Netherlands. (author)
  • Ponsonby, Anne-LouiseRoyal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia. (author)
  • Scholze, MartinBrunel University, GBR,Brunel Univ London, Inst Environm Hlth & Soc, Uxbridge UB8 3PH, Middx, England. (author)
  • Testa, GiuseppeUniv Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy. (author)
  • Tresguerres, Jesus A. E.Univ Complutense , ESP,Univ Complutense Madrid, Sch Med, Dept Physiol, Madrid 28040, Spain. (author)
  • Westerink, Remco H. S.Univ Utrecht, Fac Vet Med, Inst Risk Assessment Sci IRAS, NL-3584 CM Utrecht, Netherlands. (author)
  • Zalc, BernardSorbonne Univ, INSERM, CNRS, ICM GH Pitie Salpetriere, F-75651 Paris, France. (author)
  • Ruegg, JoelleKarolinska Institutet,Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.(Swepub:uu)joeru493 (author)
  • Uppsala universitetMiljötoxikologi (creator_code:org_t)

Related titles

  • In:International Journal of Molecular Sciences: MDPI21:111661-65961422-0067

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