Search: WFRF:(Leonards Pim E G) >
The ENDpoiNTs Proje...
The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
-
- Lupu, Diana (author)
- Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.;Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Toxicol, Cluj Napoca 400012, Romania.
-
- Andersson, Patrik L. (author)
- Umeå universitet,Kemiska institutionen,Umeå University,Umea Univ, Fac Sci & Technol, S-90187 Umea, Sweden.
-
- Bornehag, Carl-Gustav, 1957- (author)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Karlstad Univ, Dept Hlth Sci, S-65188 Karlstad, Sweden.
-
show more...
-
- Demeneix, Barbara (author)
- CNRS, Evolut Endocrine Regulat UMR 7221, F-75005 Paris, France.
-
- Fritsche, Ellen (author)
- IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany.
-
- Gennings, Chris (author)
- Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.
-
- Lichtensteiger, Walter (author)
- GREEN Tox GmbH, CH-8057 Zurich, Switzerland.
-
- Leist, Marcel (author)
- Univ Konstanz, In Vitro Toxicol & Biomed, D-78457 Constance, Germany.
-
- Leonards, Pim E. G. (author)
- Vrije University, NLD,Vrije Univ, Dept Environm & Hlth, NL-1081 HV Amsterdam, Netherlands.
-
- Ponsonby, Anne-Louise (author)
- Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.
-
- Scholze, Martin (author)
- Brunel University, GBR,Brunel Univ London, Inst Environm Hlth & Soc, Uxbridge UB8 3PH, Middx, England.
-
- Testa, Giuseppe (author)
- Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy.
-
- Tresguerres, Jesus A. E. (author)
- Univ Complutense , ESP,Univ Complutense Madrid, Sch Med, Dept Physiol, Madrid 28040, Spain.
-
- Westerink, Remco H. S. (author)
- Univ Utrecht, Fac Vet Med, Inst Risk Assessment Sci IRAS, NL-3584 CM Utrecht, Netherlands.
-
- Zalc, Bernard (author)
- Sorbonne Univ, INSERM, CNRS, ICM GH Pitie Salpetriere, F-75651 Paris, France.
-
- Ruegg, Joelle (author)
- Karolinska Institutet,Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.
-
show less...
-
(creator_code:org_t)
- 2020-06-01
- 2020
- English.
-
In: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 21:11
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://kau.diva-por... (primary) (Raw object)
-
https://www.mdpi.com...
-
https://umu.diva-por... (primary) (Raw object)
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- endocrine-disrupting chemicals
- developmental neurotoxicity
- chemical testing
- adverse outcome pathways
- Public Health Science
- Folkhälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lupu, Diana
-
Andersson, Patri ...
-
Bornehag, Carl-G ...
-
Demeneix, Barbar ...
-
Fritsche, Ellen
-
Gennings, Chris
-
show more...
-
Lichtensteiger, ...
-
Leist, Marcel
-
Leonards, Pim E. ...
-
Ponsonby, Anne-L ...
-
Scholze, Martin
-
Testa, Giuseppe
-
Tresguerres, Jes ...
-
Westerink, Remco ...
-
Zalc, Bernard
-
Ruegg, Joelle
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Pharmacology and ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Occupational Hea ...
- Articles in the publication
-
International Jo ...
- By the university
-
Karlstad University
-
Umeå University
-
Uppsala University
-
Karolinska Institutet