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Association of ambient PM2.5 exposure with maternal bone strength in pregnant women from Mexico City : a longitudinal cohort study

Wu, Haotian (författare)
Columbia University, USA
Kioumourtzoglou, Marianthi-Anna (författare)
Columbia University, USA
Just, Allan C. (författare)
Icahn School of Medicine at Mount Sinai, USA
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Kloog, Itai (författare)
Ben Gurion University, ISR
Sanders, Alison (författare)
Icahn School of Medicine at Mount Sinai, USA
Svensson, Katherine (författare)
Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)
McRae, Nia (författare)
Icahn School of Medicine at Mount Sinai, USA
Tamayo-Ortiz, Marcela (författare)
Ministry Health, National Institute of Public Health, MEX ;Mexican Council of Science & Technology, MEX
Solano-Gonzalez, Maritsa (författare)
Ministry Health, National Institute of Public Health, MEX
Wright, Robert O. (författare)
Icahn School of Medicine at Mount Sinai, USA
Tellez-Rojo, Martha M. (författare)
Ministry Health, National Institute of Public Health, MEX
Baccarelli, Andrea A. (författare)
Columbia University, USA
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 (creator_code:org_t)
2020
2020
Engelska.
Ingår i: The Lancet Planetary Health. - 2542-5196. ; 4:11, s. E530-E537
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background Pregnancy is associated with deteriorations in maternal bone strength and heightened susceptibility to bone fractures. We aimed to investigate whether ambient particulate matter (PM)(2.5) concentrations were associated with bone strength during pregnancy. Methods In this longitudinal cohort study, we analysed longitudinal data from women participating in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort in Mexico City, Mexico. Eligible women were aged 18 years or older, at less than 20 weeks' gestation at the time of recruitment, planning to stay in Mexico City for the next 3 years, without heart or kidney disease, did not use steroids or anti-epileptic drugs, were not daily consumers of alcohol, and had access to a telephone. Daily ambient PM2.5 concentrations were estimated from a spatio-temporal model that was based on the individual's address. Trabecular bone strength was measured using quantitative ultrasound from the radius of the middle finger and cortical bone strength from the proximal phalanx of the middle finger, during the second trimester, third trimester, and 1 and 6 months post partum. Bone strength T scores were modelled with PM2.5 concentrations using linear mixed models and distributed lag models. Findings Adjusting for multiple exposure windows, each 10 mu g/m(3) increase in PM2.5 exposure concentrations in the first trimester was associated with a 0.18 SD decrease (95% CI -0.35 to -0.01; p=0.033) in ultrasound speed-of-sound (SOS) T score of trabecular bone strength from the second trimester until 6 months post partum. Similarly, each 10 mu g/m(3) increase in third trimester PM2.5 exposure was associated with a 0.18 SD decrease (-0.36 to -0.01; p=0.044) in the SOS T score of trabecular bone strength from the third trimester until 6 months post partum. PM2.5 exposure in the first month post partum was associated with a 0.20 SD decline (-0.39 to -0.01; p=0.043) in cortical bone strength until 6 months post partum. Interpretation Ambient PM2.5 exposure during and after pregnancy was associated with diminished trabecular and cortical bone strength. Early pregnancy PM2.5 exposure was associated with a greater decline in bone strength later during pregnancy. Late pregnancy and early post-partum exposures adversely affected the post-partum bone strength recovery. Technological and policy solutions to reduce PM2.5 pollution could improve public health by reducing bone fracture risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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Public Health Science
Folkhälsovetenskap

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