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Sökning: WFRF:(Swan Shanna H.) > (2021) > Paracetamol use dur...

  • Bauer, Ann Z.University of Massachusetts School of Health Sciences, USA (författare)

Paracetamol use during pregnancy - a call for precautionary action

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-09-23
  • Springer Nature,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kau-86170
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-86170URI
  • https://doi.org/10.1038/s41574-021-00553-7DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. However, increasing experimental and epidemiological research suggests that prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders. Here we summarize this evidence and call for precautionary action through a focused research effort and by increasing awareness among health professionals and pregnant women. APAP is an important medication and alternatives for treatment of high fever and severe pain are limited. We recommend that pregnant women should be cautioned at the beginning of pregnancy to: forego APAP unless its use is medically indicated; consult with a physician or pharmacist if they are uncertain whether use is indicated and before using on a long-term basis; and minimize exposure by using the lowest effective dose for the shortest possible time. We suggest specific actions to implement these recommendations. This Consensus Statement reflects our concerns and is currently supported by 91 scientists, clinicians and public health professionals from across the globe. A growing body of research suggests that prenatal exposure to paracetamol (APAP) might alter development and increase the risk of some reproductive, urogenital and neurodevelopmental disorders. This Consensus Statement calls for precautionary action, including a focused research effort, increasing awareness among health professionals and pregnant women and, whenever possible, minimizing use.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Swan, Shanna H.Icahn School of Medicine at Mount Sinai, USA (författare)
  • Kriebel, DavidUniversity of Massachusetts School of Health Sciences, USA (författare)
  • Liew, ZeyanYale School of Public Health, USA (författare)
  • Taylor, Hugh S.Yale School of Public Health, USA (författare)
  • Bornehag, Carl-Gustav,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai, USA(Swepub:kau)caguborn (författare)
  • Andrade, Anderson M.Universidade Federal do Paraná (UFPR), BRA (författare)
  • Olsen, JornAarhus University, DNK (författare)
  • Jensen, Rigmor H.University of Copenhagen, DNK (författare)
  • Mitchell, Rod T.Queens Medical Research Institute, GBR (författare)
  • Skakkebaek, Niels E.University of Copenhagen, DNK (författare)
  • Jegou, BernardUniv Rennes, FRA (författare)
  • Kristensen, David M.University of Copenhagen, DNK; Univ Rennes, FRA (författare)
  • University of Massachusetts School of Health Sciences, USAIcahn School of Medicine at Mount Sinai, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Reviews Endocrinology: Springer Nature17, s. 757-7661759-50291759-5037

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