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  • Sindi, S.Karolinska Institutet (author)

Multimodal Preventive Trial for Alzheimer’s Disease : MIND-ADmini Pilot Trial Study Design and Progress

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022
  • Serdi-Editions,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kau-89076
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-89076URI
  • https://doi.org/10.14283/jpad.2022.4DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-89322URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468394URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148607634URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Validerad;2022;Nivå 2;2022-02-17 (johcin);Funder: EU Joint Programme - Neurodegenerative Disease Research (JPND), for more details, see: https://link.springer.com/article/10.14283/jpad.2022.4#Ack1
  • Background: Interventions simultaneously targeting multiple risk factors and mechanisms are most likely to be effective in preventing cognitive impairment. This was indicated in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) testing a multidomain lifestyle intervention among at-risk individuals. The importance of medical food at the early symptomatic disease stage, prodromal Alzheimer’s disease (AD), was emphasized in the LipiDiDiet trial. The feasibility and effects of multimodal interventions in prodromal AD are unclear. Objectives: To evaluate the feasibility of an adapted FINGER-based multimodal lifestyle intervention, with or without medical food, among individuals with prodromal AD. Methods: MIND-ADmini is a multinational proof-of-concept 6-month randomized controlled trial (RCT), with four trial sites (Sweden, Finland, Germany, France). The trial targeted individuals with prodromal AD defined using the International Working Group-1 criteria, and with vascular or lifestyle-related risk factors. The parallel-group RCT includes three arms: 1) multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); 2) multimodal lifestyle intervention+medical food (Fortasyn Connect); and 3) regular health advice/ care (control group). Primary outcomes are feasibility and adherence. Secondary outcomes are adherence to the individual intervention domains and healthy lifestyle changes. Results: Screening began on 28 September 2017 and was completed on 21 May 2019. Altogether 93 participants were randomized and enrolled. The intervention proceeded as planned. Conclusions: For the first time, this pilot trial tests the feasibility and adherence to a multimodal lifestyle intervention, alone or combined with medical food, among individuals with prodromal AD. It can serve as a model for combination therapy trials (non-pharma, nutrition-based and/or pharmacological interventions).

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
  • MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
  • Alzheimer’s disease
  • Dementia
  • intervention
  • lifestyle
  • multimodal
  • prevention
  • randomized controlled trial
  • aged
  • Alzheimer disease
  • Article
  • cardiometabolic risk
  • cognitive therapy
  • cohort analysis
  • controlled study
  • exercise
  • feasibility study
  • female
  • Finland
  • France
  • Germany
  • healthy lifestyle
  • human
  • lifestyle modification
  • major clinical study
  • male
  • multicenter study
  • nutritional support
  • outcome assessment
  • parallel design
  • patient compliance
  • patient counseling
  • pilot study
  • prevention study
  • prodromal symptom
  • proof of concept
  • prophylaxis
  • risk factor
  • risk management
  • Sweden
  • Psychology with an emphasis on medical psychology
  • Psykologi inr. medicinsk psykologi
  • Engineering Psychology

Added entries (persons, corporate bodies, meetings, titles ...)

  • Thunborg, C.Karolinska Institutet (author)
  • Rosenberg, A.Karolinska Institutet (author)
  • Andersen, P.Karolinska Institutet (author)
  • Andrieu, S.Karolinska Institutet (author)
  • Broersen, L. M.Danone Nutricia Research, NLD,Danone Nutricia Research, Advanced Medical Nutrition, Utrecht, The Netherlands (author)
  • Coley, N.University of Toulouse, FRA,Department of Clinical Epidemiology and Public health, CHU de Toulouse, and INSERM, University of Toulouse, UMR1027, Toulouse, France (author)
  • Couderc, C.University of Toulouse, FRA,Department of Clinical Epidemiology and Public health, CHU de Toulouse, and INSERM, University of Toulouse, UMR1027, Toulouse, France,German Institute for Dementia Prevention (DIDP), Saarland University, Homburg, Germany; Institute of General Practice, Goethe University, Frankfurt a.M., Germany,Saarland University, DEU ; Goethe University, DEU (author)
  • Duval, C. Z.Saarland University, DEU ; Goethe University, DEU (author)
  • Faxen-Irving, G.Karolinska Institutet (author)
  • Hagman, G.Karolinska Institutet (author)
  • Hallikainen, M.University of Eastern Finland, FIN,Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (author)
  • Håkansson, K.Karolinska Institutet (author)
  • Lehtisalo, J.University of Eastern Finland, FIN : Uppsala University,Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (author)
  • Levak, N.Karolinska Institutet (author)
  • Mangialasche, F.Karolinska Institutet (author)
  • Pantel, J.Saarland University, DEU ; Goethe University, DEU,German Institute for Dementia Prevention (DIDP), Saarland University, Homburg, Germany; Institute of General Practice, Goethe University, Frankfurt a.M., Germany (author)
  • Kekkonen, E.University of Eastern Finland, FIN,Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (author)
  • Rydström, A.Karolinska Institutet (author)
  • Stigsdotter Neely, Anna,1961-Luleå tekniska universitet,Karlstads universitet,Institutionen för sociala och psykologiska studier (from 2013),Luleå University,Hälsa, medicin och rehabilitering,Department of Social and Psychological Studies, Karlstad University, Karlstad, Sweden(Swepub:ltu)annsti (author)
  • Wimo, A.Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Karolinska institutet (author)
  • Ngandu, T.Karolinska Institutet (author)
  • Soininen, H.University of Eastern Finland, FIN,Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (author)
  • Hartmann, T.Saarland University, DEU,German Institute for Dementia Prevention (DIDP), Saarland University, Homburg, Germany; Department of Experimental Neurology, Medical Faculty, Saarland University, Homburg, Germany (author)
  • Solomon, A.Karolinska Institutet ; Imperial College, GBR ; University of Eastern Finland, FIN (author)
  • Kivipelto, M.Karolinska Institutet (author)
  • Karolinska InstitutetDanone Nutricia Research, NLD (creator_code:org_t)

Related titles

  • In:The Journal of Prevention of Alzheimer's Disease: Serdi-Editions9:1, s. 30-392274-58072426-0266

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