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Heterogeneous sensi...
Heterogeneous sensitivity of cerebral and muscle tissues to acute normobaric hyperoxia at rest
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- Keramidas, Michail E. (författare)
- KTH,Omgivningsfysiologi
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Kounalakis, Stylianos N. (författare)
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Geladas, Nickos D. (författare)
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visa fler...
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- Eiken, Ola (författare)
- KTH,Omgivningsfysiologi
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Mekjavic, Igor B. (författare)
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visa färre...
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Microvascular Research. - : Elsevier BV. - 0026-2862 .- 1095-9319. ; 84:2, s. 205-210
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The purpose was to investigate the effects of acute normobaric hyperoxia at rest on cerebral, respiratory and leg muscle oxygenation. Ten healthy men were studied twice in a single-blinded counterbalanced crossover study protocol. On one occasion they breathed air and on the other 100% normobaric O-2 for a 2-hour time period. Oxygenated (Delta[O(2)Hb]), deoxygenated (Delta[HHb]) and total (Delta[tHb]) hemoglobin in the cerebral frontal cortex, and in the intercostal and vastus lateralis muscles were simultaneously monitored with near-infrared spectroscopy. The hyperoxic stimulus promptly increased Delta[O(2)Hb] (similar to 2 mu M) and decreased Delta[HHb] (similar to 3.6 mu M) in the frontal cortex. These cerebral responses were directly and fully countered by resumption of normoxic air breathing. In contrast, Delta[HHb] significantly decreased due to the acute hyperoxic stimulus in both intercostal and vastus lateralis muscles. The temporal changes in muscle oxygenation were slower compared to those in the cerebral area; and they only partially recovered during the 15-min normoxic-recovery period. Acute supplementation of normobaric O-2 at rest influences cerebral, leg and respiratory muscle oxygenation of healthy individuals, but not in the same manner. Namely, the frontal cortex seems to be more sensitive to hyperoxia than are the skeletal muscle regions.
Nyckelord
- Near-Infrared Spectroscopy
- Human Skeletal-Muscle
- Blood-Flow
- Oxygen-Consumption
- Healthy-Volunteers
- O-2 Consumption
- Conscious Dogs
- Heart-Rate
- Exercise
- Humans
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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