Flow-free transport of cells in microchannels by frequency-modulated ultrasound

QC 20100730
We demonstrate flow-free transport of cells and particles by the use of frequency-modulated ultrasonic actuation of a microfluidic chip. Two different modulation schemes are combined: A rapid (1 kHz) linear frequency sweep around similar to 6.9 MHz is used for two-dimensional spatial stabilization of the force field over a 5 mm long inlet channel of constant cross section, and a slow (0.2-0.7 Hz) linear frequency sweep around similar to 2.6 MHz is used for flow-free ultrasonic transport and positioning of cells or particles. The method is used for controlling the motion and position of cells monitored with high-resolution optical microscopy, but can also be used more generally for improving the robustness and performance of ultrasonic manipulation micro-devices.

Vanherberghen, BrunoKTH,Tillämpad fysik,Cell Physics(Swepub:kth)u11pslz9 (författare)
Önfelt, BjörnKTH,Tillämpad fysik,Cell Physics(Swepub:kth)u1tquq43 (författare)
Wiklund, MartinKTH,Tillämpad fysik,Biomedical & X-Ray Physics(Swepub:kth)u1rillco (författare)
KTHTillämpad fysik (creator_code:org_t)

Av författaren/redakt...: Manneberg, Otto; Vanherberghen, B ...; Önfelt, Björn; Wiklund, Martin

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.