(hsv:(NATURVETENSKAP) hsv:(Biologi) hsv:(Biokemi och molekylärbiologi)) pers:(Uhlen Mathias)
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- Danielsson, FridaKTH,Science for Life Laboratory, SciLifeLab,HPR/M UHLÉN (author)
Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013-04-08
- Proceedings of the National Academy of Sciences,2013
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-123630
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123630URI
- https://doi.org/10.1073/pnas.1216436110DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:126733651URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-91175URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-201818URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20130614
- AuthorCount:10;
- The transformation of normal cells to malignant, metastatic tumor cells is a multistep process caused by the sequential acquirement of genetic changes. To identify these changes, we compared the transcriptomes and levels and distribution of proteins in a four-stage cell model of isogenically matched normal, immortalized, transformed, and metastatic human cells, using deep transcriptome sequencing and immunofluorescence microscopy. The data show that similar to 6% (n = 1,357) of the human protein-coding genes are differentially expressed across the stages in the model. Interestingly, the majority of these genes are down-regulated, linking malignant transformation to dedifferentiation. The up-regulated genes are mainly components that control cellular proliferation, whereas the down-regulated genes consist of proteins exposed on or secreted from the cell surface. As many of the identified gene products control basic cellular functions that are defective in cancers, the data provide candidates for follow-up studies to investigate their functional roles in tumor formation. When we further compared the expression levels of four of the identified proteins in clinical cancer cohorts, similar differences were observed between benign and cancer cells, as in the cell model. This shows that this comprehensive demonstration of the molecular changes underlying malignant transformation is a relevant model to study the process of tumor formation.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- Breast-Cancer
- Annexin A1
- Cell-Migration
- Tumor-Growth
- T-Antigen
- Carcinogenesis
- Metastasis
- Hallmarks
- Carcinoma
- Oncogenes
Added entries (persons, corporate bodies, meetings, titles ...)
- Skogs, MarieKTH,Proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1hik3sg (author)
- Huss, MikaelStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab) (author)
- Rexhepaj, EltonKTH,Science for Life Laboratory, SciLifeLab,HPR/M UHLÉN(Swepub:kth)u1ylzfxm (author)
- O'Hurley, GillianUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)giloa651 (author)
- Klevebring, DanielKarolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)u10ab3gt (author)
- Pontén, FredrikUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)fredpont (author)
- Gad, Annica K. B.Karolinska Institutet (author)
- Uhlén, MathiasKTH,Proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw (author)
- Lundberg, EmmaKTH,Proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u12bylj1 (author)
- KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)
Related titles
- In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences110:17, s. 6853-68580027-84241091-6490
Internet link
- https://www.pnas.org/content/pnas/110/17/6853.full.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123630
- https://doi.org/10.1073/pnas.1216436110
- http://kipublications.ki.se/Default.aspx?queryparsed=id:126733651
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-91175
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-201818
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