Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications

• A new method that allows for mold-free, rapid and easy-to-use proto- typing of micro uidic devices comprising channels, access holes and surface modied patterns, is presented. The innovative method is based on direct photolithographic patterning of an o-stoichiometry thiol-ene (OSTE) polymer formulation, tailor-made for photolithography, which oers unprecedented spatial resolution and allow for ecient, robust and reliable, room temperature surface modication and glue-free, covalent room temperature bonding. This mold-free process does not require cleanroom equipment and therefore allows for rapid, i.e. less than one hour, design-fabricate-test cycles, using a material suited for larger scale production. The excellent photolithographic properties of this new OSTE formulation allow for high-resolution patterning in hundreds of micrometers thick layers, 200 m thick in this work. Moreover, we demonstrate robust (covalent) and spatially controlled modication of the microchannel surfaces with a contact angle of 76 degrees to hydrophobic/hydrophilic areas with contact angles of 102 and 43 degrees, respectively.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Nanoteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Nano-technology (hsv//eng)

Nyckelord

lab-on-chip

microfluidics

photolithography

OSTE polymer

surface modi

oste

oste

OSTEmer

lab-on-chip

off-stoichiometric thiol-ene

Bioteknologi

Biotechnology

Teknisk materialvetenskap

Materials Science and Engineering

Publikations- och innehållstyp

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