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- Zong, N. C. (author)
Integration of cardiac proteome biology and medicine by a specialized knowledgebase
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-140053
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-140053URI
- https://doi.org/10.1161/CIRCRESAHA.113.301151DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20140120
- Rationale: Omics sciences enable a systems-level perspective in characterizing cardiovascular biology. Integration of diverse proteomics data via a computational strategy will catalyze the assembly of contextualized knowledge, foster discoveries through multidisciplinary investigations, and minimize unnecessary redundancy in research efforts. Objective: The goal of this project is to develop a consolidated cardiac proteome knowledgebase with novel bioinformatics pipeline and Web portals, thereby serving as a new resource to advance cardiovascular biology and medicine. Methods and results: We created Cardiac Organellar Protein Atlas Knowledgebase (COPaKB; www.HeartProteome.org), a centralized platform of high-quality cardiac proteomic data, bioinformatics tools, and relevant cardiovascular phenotypes. Currently, COPaKB features 8 organellar modules, comprising 4203 LC-MS/MS experiments from human, mouse, drosophila, and Caenorhabditis elegans, as well as expression images of 10 924 proteins in human myocardium. In addition, the Java-coded bioinformatics tools provided by COPaKB enable cardiovascular investigators in all disciplines to retrieve and analyze pertinent organellar protein properties of interest. Conclusions: COPaKB provides an innovative and interactive resource that connects research interests with the new biological discoveries in protein sciences. With an array of intuitive tools in this unified Web server, nonproteomics investigators can conveniently collaborate with proteomics specialists to dissect the molecular signatures of cardiovascular phenotypes.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
- Computational biology
- COPaKB
- Mitochondria
- Omics science
- Organelles
- Proteomics
- Translational medical research
- protein
- proteome
- article
- bioinformatics
- Caenorhabditis elegans
- cardiology
- Drosophila
- heart muscle
- human
- nonhuman
- phenotype
- priority journal
Added entries (persons, corporate bodies, meetings, titles ...)
- Li, H. (author)
- Lam, M. P. Y. (author)
- Jimenez, R. C. (author)
- Kim, C. S. (author)
- Deng, N. (author)
- Kim, A. K. (author)
- Choi, J. H. (author)
- Zelaya, I. (author)
- Liem, D. (author)
- Meyer, D. (author)
- Odeberg, JacobKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1e4yljo (author)
- Fang, C. (author)
- Lu, H. -J (author)
- Xu, T. (author)
- Weiss, J. (author)
- Duan, H. (author)
- Uhlén, MathiasKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw (author)
- Yates III, J. R. (author)
- Apweiler, R. (author)
- Ge, J. (author)
- Hermjakob, H. (author)
- Ping, P. (author)
- KTHProteomik och nanobioteknologi (creator_code:org_t)
Related titles
- In:Circulation Research113:9, s. 1043-10530009-73301524-4571
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- Zong, N. C.
- Li, H.
- Lam, M. P. Y.
- Jimenez, R. C.
- Kim, C. S.
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- Kim, A. K.
- Choi, J. H.
- Zelaya, I.
- Liem, D.
- Meyer, D.
- Odeberg, Jacob
- Fang, C.
- Lu, H. -J
- Xu, T.
- Weiss, J.
- Duan, H.
- Uhlén, Mathias
- Yates III, J. R.
- Apweiler, R.
- Ge, J.
- Hermjakob, H.
- Ping, P.
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