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Sökning: WFRF:(Birner A) > (2014) > Variations of disse...

  • Tong, J. (författare)

Variations of dissection properties and mass fractions with thrombus age in human abdominal aortic aneurysms

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-140824
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-140824URI
  • https://doi.org/10.1016/j.jbiomech.2013.10.027DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20140204
  • Introduction: Thrombus ages, defined as four relative age phases, are related to different compositions of the intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) (Tong et al., 2011b). Experimental studies indicate a correlation between the relative thrombus age and the strength of the thrombus-covered wall. Methods: On 32 AAA samples we performed peeling tests with the aim to dissect the material (i) through the ILT thickness, (ii) within the individual ILT layers and (iii) within the aneurysm wall underneath the thrombus by using two extension rates (1. mm/min, 1. mm/s). Histological investigations and mass fraction analysis were performed to characterize the dissected morphology, to determine the relative thrombus age, and to quantify dry weight percentages of elastin and collagen in the AAA wall. Results: A remarkably lower dissection energy was needed to dissect within the individual ILT layers and through the thicknesses of old thrombi. With increasing ILT age the dissection energy of the underlying intima-media composite continuously decreased and the anisotropic dissection properties for that composite vanished. The quantified dissection properties were rate dependent for both tissue types (ILT and wall). Histology showed that single fibrin fibers or smaller protein clots within the ILT generate smooth dissected surfaces during the peeling. There was a notable decrease in mass fraction of elastin within the thrombus-covered intima-media composite with ILT age, whereas no significant change was found for that of collagen. Conclusions: These findings suggest that intraluminal thrombus aging leads to a higher propensity of dissection for the ILT and the intima-media composite of the aneurysmal wall.

Ämnesord och genrebeteckningar

  • Dissection
  • Intraluminal thrombus
  • Mass fraction
  • Thrombus age
  • Thrombus-covered wall

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Cohnert, T. (författare)
  • Regitnig, P. (författare)
  • Kohlbacher, J. (författare)
  • Birner-Gruenberger, R. (författare)
  • Schriefl, A. J. (författare)
  • Sommer, G. (författare)
  • Holzapfel, Gerhard A.KTH,Hållfasthetslära (Inst.)(Swepub:kth)u1esp3uu (författare)
  • KTHHållfasthetslära (Inst.) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Biomechanics: Elsevier BV47:1, s. 14-230021-92901873-2380

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