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  • Jakobsson, Hedvig E.Dept Preparedness, Swedish Inst Communicable Dis Control, Solna, Sweden; Dept Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden,Department of Preparedness, Swedish Institute for Communicable Disease Control, Solna, Sweden (författare)

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • 2013-08-07
  • London :BMJ,2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-146571
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-146571URI
  • https://doi.org/10.1136/gutjnl-2012-303249DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35355URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102209URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:128984958URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20140613
  • Funding Agencies:Ekhaga Foundation and the Soderbergs FoundationResearch Council for the South-East SwedenSwedish Asthma and Allergy AssociationOlle Engkvist FoundationVardal Foundation-for Health Care Sciences and Allergy ResearchSwedish Research Councils VRUnilever
  • important stimuli for immune development, and a reduced microbial exposure as well as caesarean section (CS) has been associated with the development of allergic disease. Here we address how microbiota development in infants is affected by mode of delivery, and relate differences in colonisation patterns to the maturation of a balanced Th1/Th2 immune response. Design The postnatal intestinal colonisation pattern was investigated in 24 infants, born vaginally (15) or by CS (nine). The intestinal microbiota were characterised using pyrosequencing of 16S rRNA genes at 1 week and 1, 3, 6, 12 and 24 months after birth. Venous blood levels of Th1- and Th2-associated chemokines were measured at 6, 12 and 24 months. Results Infants born through CS had lower total microbiota diversity during the first 2 years of life. CS delivered infants also had a lower abundance and diversity of the Bacteroidetes phylum and were less often colonised with the Bacteroidetes phylum. Infants born through CS had significantly lower levels of the Th1-associated chemokines CXCL10 and CXCL11 in blood. Conclusions CS was associated with a lower total microbial diversity, delayed colonisation of the Bacteroidetes phylum and reduced Th1 responses during the first 2 years of life.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Abrahamsson, ThomasÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)thoab97 (författare)
  • Jenmalm, Maria CLinköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet(Swepub:liu)marje18 (författare)
  • Harris, KeithSchool of Engineering, Univ Glasgow, Glasgow, UK,School of Engineering, University of Glasgow, Glasgow, UK (författare)
  • Quince, ChristopherSch Engn, Univ Glasgow, Glasgow, UK,School of Engineering, University of Glasgow, Glasgow, UK (författare)
  • Jernberg, CeciliaDept Preparedness, Swedish Inst Communicable Dis Control, Solna, Sweden,Department of Preparedness, Swedish Institute for Communicable Disease Control, Solna, Sweden (författare)
  • Björkstén, Bengt,1940-Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Inst Environm Med, Karolinska Inst, Stockholm, Sweden,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)bbn (författare)
  • Engstrand, LarsKarolinska Institutet (författare)
  • Andersson, Anders F.KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Sci Life Lab, Sch Biotechnol, Div Gene Technol, KTH Royal Inst Technol, Solna, Sweden,KTH Royal Institute of Technology, Science for Life Laboratory, School of Biotechnology, Division of Gene Technology, Solna, Sweden(Swepub:kth)u1hi776x (författare)
  • Dept Preparedness, Swedish Inst Communicable Dis Control, Solna, Sweden; Dept Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, SwedenDepartment of Preparedness, Swedish Institute for Communicable Disease Control, Solna, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:GutLondon : BMJ63:4, s. 559-5660017-57491468-3288

Internetlänk

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  • Gut (Sök värdpublikationen i LIBRIS)

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