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Synergy between she...
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Biasetti, JacopoKTH,Hållfasthetslära (Inst.)
(author)
Synergy between shear-induced migration and secondary flows on red blood cells transport in arteries : considerations on oxygen transport
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-08-06
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The Royal Society,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-148600
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-148600URI
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https://doi.org/10.1098/rsif.2014.0403DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129380687URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20140812
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Shear-induced migration of red blood cells (RBCs) is a well-known phenomenon characterizing blood flow in the small vessels (micrometre to millimetre size) of the cardiovascular system. In large vessels, like the abdominal aorta and the carotid artery (millimetre to centimetre size), the extent of this migration and its interaction with secondary flows has not been fully elucidated. RBC migration exerts its influence primarily on platelet concentration, oxygen transport and oxygen availability at the luminal surface, which could influence vessel wall disease processes in and adjacent to the intima. Phillips' shear-induced particle migration model, coupled to the Quemada viscosity model, was employed to simulate the macroscopic behaviour of RBCs in four patient-specific geometries: a normal abdominal aorta, an abdominal aortic aneurysm (AAA), a normal carotid bifurcation and a stenotic carotid bifurcation. Simulations show a migration of RBCs from the near-wall region with a lowering of wall haematocrit (volume fraction of RBCs) on the posterior side of the normal aorta and on the lateral-external side of the iliac arteries. A marked migration is observed on the outer wall of the carotid sinus, along the common carotid artery and in the carotid stenosis. No significant migration is observed in the AAA. The spatial and temporal patterns of wall haematocrit are correlated with the near-wall shear layer and with the secondary flows induced by the vessel curvature. In particular, secondary flows accentuate the initial lowering in RBC near-wall concentration by convecting RBCs from the inner curvature side to the outer curvature side. The results reinforce data in literature showing a decrease in oxygen partial pressure on the inner curvature wall of the carotid sinus induced by the presence of secondary flows. The lowering of wall haematocrit is postulated to induce a decrease in oxygen availability at the luminal surface through a diminished concentration of oxyhaemoglobin, hence contributing, with the reported lowered oxygen partial pressure, to local hypoxia.
Subject headings and genre
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secondary flow
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shear-induced migration
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red blood cells
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oxygen transport
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haemoglobin
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artery
Added entries (persons, corporate bodies, meetings, titles ...)
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Spazzini, Pier Giorgio
(author)
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Hedin, UlfKarolinska Institutet
(author)
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Gasser, T. Christian
(author)
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KTHHållfasthetslära (Inst.)
(creator_code:org_t)
Related titles
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In:Journal of the Royal Society Interface: The Royal Society11:97, s. 20140403-1742-56891742-5662
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