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Crystal growth rates of paracetamol in mixtures of water plus acetone plus toluene

Granberg, R. A. (author)
Rasmuson, Åke C. (author)
KTH,Teknisk strömningslära
 (creator_code:org_t)
2005
2005
English.
In: AIChE Journal. - : Wiley. - 0001-1541 .- 1547-5905. ; 51:9, s. 2441-2456
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Crystal growth rates of paracetamol (4-hydroxyacetanilide) have been determined by seeded isothermal desupersaturation experiments at 16 degrees C in 23 different solvent mixtures of water + acetone + toluene. Parameters of different growth rate equations have been estimated by direct nonlinear optimization. At equal thermodynamic driving force, the growth rate depends on the composition of the solvent mixture. In the surface diffusion spiral growth model, this dependency can be described in terms of the interfacial energy between the solid and the solution. A reasonable prediction of the influence of the solvent composition on this interfacial energy is obtained if a proper estimation of the enthalpy of dissolution is done. For the case of paracetamol crystals growing in water + acetone + toluene mixtures this estimation needs to include an estimation of the entropy of fusion at the temperature of growth as well as of the nonideal entropy of mixing.

Keyword

crystallization
crystal growth
solvents
interfacial energy
puracetamol
chemical potential driving force
structurally related substances
succinic acid crystals
para-hydroxyacetanilide
roughening transition
interfacial-tensions
orthorhombic form
aqueous-solutions
liquid-mixtures
crystallization
solubility

Publication and Content Type

ref (subject category)
art (subject category)

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Granberg, R. A.
Rasmuson, Åke C.
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AIChE Journal
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Royal Institute of Technology

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