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  • Arias, VeluskaKTH,Fiber- och polymerteknologi (author)

Nano-Stereocomplexation of Polylactide (PLA) Spheres by Spray Droplet Atomization

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-09-29
  • Wiley,2014
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:kth-158321
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-158321URI
  • https://doi.org/10.1002/marc.201400374DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20150126
  • A direct, efficient, and scalable method to prepare stereocomplexed polylactide (PLA)-based nanoparticles (NPs) is achieved. By an appropriate combination of fabrication parameters, NPs with controlled shape and crystalline morphology are obtained and even pure PLA stereocomplexes (PLASC) are successfully prepared using the spray-drying technology. The formed particles of varying D- and L-LA content have an average size of approximate to 400 nm, where the smallest size is obtained for PLA50, which has an equimolar composition of PLLA and PDLA in solution. Raman spectra of the particles show the typical shifts for PLASC in PLA50, and thermal analysis indicates the presence of pure stereocomplexation, with only one melting peak at 226 degrees C. Topographic images of the particles exhibit a single phase with different surface roughness in correlation with the thermal analysis. A high yield of spherically shaped particles is obtained. The results clearly provide a proficient method for achieving PLASC NPs that are expected to function as renewable materials in PLA-based nanocomposites and potentially as more stable drug delivery carriers.

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  • Odelius, KarinKTH,Fiber- och polymerteknologi(Swepub:kth)u12viu57 (author)
  • Albertsson, Ann-ChristineKTH,Fiber- och polymerteknologi(Swepub:kth)u1mpsp3u (author)
  • KTHFiber- och polymerteknologi (creator_code:org_t)

Related titles

  • In:Macromolecular rapid communications: Wiley35:22, s. 1949-19531022-13361521-3927

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By the author/editor
Arias, Veluska
Odelius, Karin
Albertsson, Ann- ...
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ENGINEERING AND TECHNOLOGY
ENGINEERING AND ...
and Chemical Enginee ...
and Polymer Technolo ...
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Macromolecular r ...
By the university
Royal Institute of Technology

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