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Single-step manufac...
Single-step manufacturing of femtoliter microwell arrays in a novel surface energy mimicking polymer
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- Decrop, Deborah (author)
- KU Leuven, Belgium
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- Pardon, Gaspard, 1983- (author)
- KTH,Mikro- och nanosystemteknik
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- Kokalj, Tadej (author)
- KU Leuven, Belgium
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- Robert, Puers (author)
- KU Leuven, Belgium
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- Haraldsson, Tommy (author)
- KTH,Mikro- och nanosystemteknik
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- Lammertyn, Jeroen (author)
- KU Leuven, Belgium
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- van der Wijngaart, Wouter (author)
- KTH,Mikro- och nanosystemteknik
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(creator_code:org_t)
- IEEE, 2015
- 2015
- English.
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In: 18th International Conference on Solid-State Sensors, Actuators and Microsystems (IEEE TRANSDUCER 2015). - : IEEE.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We report a novel polymer material formulation and stamp-molding technique that enable rapid single-step manufacturing of hydrophilic-in-hydrophobic microwell arrays. We developed a modified thiol-ene-epoxy polymer (mOSTE+) formulation that mimics the surface energy of its mold during polymerization. The polymer inherits the surface energy from the mold through molecular self-assembly, in which functional monomers self-assemble at the interface between the liquid prepolymer and the mold surface. Combining this novel mOSTE+ material with a stamp-molding process leads to simultaneous surface energy mimicking and micro-structuring. This method was used to manufacture microwells with hydrophilic bottom and hydrophobic sidewall, depressed in a surrounding hydrophobic surface. The microwell arrays were successfully tested for the self-assembly of 62’000 femtoliter-droplets. Such femtoliter droplet arrays are useful for, e.g., digital ELISA and single cell/molecule analysis applications.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Annan elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Other Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Textil-, gummi- och polymermaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Textile, Rubber and Polymeric Materials (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
Keyword
- OSTE
- microarray
- bioassay
- biosensor
- diagnostics
- lab-on-chip
- loc
- microfluidics
- OSTEmer
- surface modification
- microwell
- microwell array
- Teknisk materialvetenskap
- Materials Science and Engineering
- Electrical Engineering
- Elektro- och systemteknik
- Bioteknologi
- Biotechnology
- Fiber- och polymervetenskap
- Fibre and Polymer Science
- Medical Technology
- Medicinsk teknologi
Publication and Content Type
- ref (subject category)
- kon (subject category)
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