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High throughput seq...
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Wang, Chunlin
(författare)
High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-01-04
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Proceedings of the National Academy of Sciences,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-159904
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-159904URI
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https://doi.org/10.1073/pnas.0913939107DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20150211
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Developing T cells face a series of cell fate choices in the thymus and in the periphery. The role of the individual T cell receptor (TCR) in determining decisions of cell fate remains unresolved. The stochastic/selection model postulates that the initial fate of the cell is independent of TCR specificity, with survival dependent on additional TCR/coreceptor "rescue" signals. The "instructive" model holds that cell fate is initiated by the interaction of the TCR with a cognate peptide-MHC complex. T cells are then segregated on the basis of TCR specificity with the aid of critical coreceptors and signal modulators [Chan S, Correia-Neves M, Benoist C, Mathis (1998) Immunol Rev 165: 195-207]. The former would predict a random representation of individual TCR across divergent T cell lineages whereas the latter would predict minimal overlap between divergent T cell subsets. To address this issue, we have used high-throughput sequencing to evaluate the TCR distribution among key T cell developmental and effector subsets from a single donor. We found numerous examples of individual subsets sharing identical TCR sequence, supporting a model of a stochastic process of cell fate determination coupled with dynamic patterns of clonal expansion of T cells bearing the same TCR sequence among both CD4(+) and CD8+ populations.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sanders, Catherine M.
(författare)
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Yang, Qunying
(författare)
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Schroeder, Harry W., Jr.
(författare)
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Wang, Elijah
(författare)
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Babrzadeh, FarbodStanford Genome Technology Center, United States(Swepub:kth)u1urz0h6
(författare)
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Gharizadeh, Baback
(författare)
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Myers, Richard M.
(författare)
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Hudson, James R., Jr.
(författare)
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Davis, Ronald W.
(författare)
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Han, Jian
(författare)
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Stanford Genome Technology Center, United States
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences107:4, s. 1518-15230027-84241091-6490
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Wang, Chunlin
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Sanders, Catheri ...
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Yang, Qunying
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Schroeder, Harry ...
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Wang, Elijah
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Babrzadeh, Farbo ...
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visa fler...
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Gharizadeh, Baba ...
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Myers, Richard M ...
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Hudson, James R. ...
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Davis, Ronald W.
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Han, Jian
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visa färre...
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