Carbon-monoxide-releasing molecules for the delivery of therapeutic co in vivo

QC 20150311
The development of carbon-monoxide-releasing molecules (CORMs) as pharmaceutical agents represents an attractive and safer alternative to administration of gaseous CO. Most CORMs developed to date are transition-metal carbonyl complexes. Although such CORMs have showed promising results in the treatment of a number of animal models of disease, they still lack the necessary attributes for clinical development. Described in this Minireview are the methods used for CORM selection, to date, and how new insights into the reactivity of metal-carbonyl complexes in vivo, together with advances in methods for live-cell CO detection, are driving the design and synthesis of new CORMs, CORMs that will enable controlled CO release in vivo in a spatial and temporal manner without affecting oxygen transport by hemoglobin.

Bernardes, Gonçalo J.L.KTH,Fiber- och polymerteknologi(Swepub:kth)PI000000 (författare)
University of Cambridge, UKFiber- och polymerteknologi (creator_code:org_t)

Ingår i:Angewandte Chemie International Edition: Wiley53:37, s. 9712-97211433-78511521-3773

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.