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7.18 C-X Bond Forma...
7.18 C-X Bond Formation : Transaminases as Chiral Catalysts: Mechanism, Engineering, and Applications
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- Berglund, Per (author)
- KTH,Biokemi
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Svedendahl Humble, Maria (author)
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Branneby, Cecilia (author)
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(creator_code:org_t)
- Elsevier, 2012
- 2012
- English.
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In: Comprehensive Chirality. - : Elsevier. - 9780080951683 ; , s. 390-401
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Enantiomerically pure amines and amino acids are important building blocks in academic research as well as in industrial-scale chemical production. Transaminases are versatile enzymes providing access to such compounds of high enantiomeric excess. This chapter illustrates the available strategies with transaminases such as kinetic resolution or stereoselective synthesis and highlights many successful examples for amino acid and chiral amines synthesis. There are some known challenges linked to the use of transaminases, for example in terms of unfavorable equilibria and inhibition. Several successful examples to overcome these limitations are presented. Also, the classification of transaminases, mechanistic details, and various strategies for optimization are discussed.
Subject headings
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Keyword
- Amino acids
- Aminotransferase
- Chiral amines
- Enzyme engineering
- Equilibrium displacement
- Product inhibition
- Pyridoxal 5'-phosphate
Publication and Content Type
- ref (subject category)
- kap (subject category)
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