Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression.

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Williams, Cecilia,1969-Karolinska Institutet (author)

Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression.

Article/chapterEnglish2009

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2009-05-08
Springer Science and Business Media LLC,2009
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LIBRIS-ID:oai:DiVA.org:kth-165362
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-165362URI
https://doi.org/10.1186/bcr2256DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:119266932URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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QC 20150428
INTRODUCTION: Mammary stem cells are bipotential and suggested to be the origin of breast cancer development, but are elusive and vaguely characterized. Breast tumors can be divided into subgroups, each one requiring specific treatment. To determine a possible association between mammary stem cells and breast cancer, a detailed characterization of the transcriptome in mammary stem cells is essential.METHODS: We have used a murine mammary epithelial stem-like cell line (HC11) and made a thorough investigation of global gene-expression changes during stepwise differentiation using dual-color comparative microarray technique. Subsequently, we have performed a cross-species comparison to reveal conserved gene expression between stem cells and subtype-specific and prognosis gene signatures, and correlated gene expression to in vivo mammary gland development.RESULTS: Our analysis of mammary stem-like and stepwise cell differentiation, and an in-depth description of our findings in a breast cancer perspective provide a unique map of the transcriptomic changes and a number of novel mammary stem cell markers. We correlate the alterations to in vivo mammary gland differentiation, and describe novel changes in nuclear receptor gene expression. Interestingly, our comparisons show that specific subtypes of breast cancers with poor prognosis and metastasizing capabilities show resemblance to stem-like gene expression.CONCLUSIONS: The transcriptional characterization of these mammary stem-like cells and their differentiation-induced gene expression patterns is here made widely accessible and provides a basis for research on mammary stem-like cells. Our comparisons suggest that some tumors are more stem-like than others, with a corresponding worse prognosis. This information would, if established, be important for treatment decisions. We also suggest several marker candidates valuable to investigate further.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
SRA - Molecular Bioscience
SRA - Molekylär biovetenskap

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Helguero, LuisaKarolinska Institutet, Sweden (author)
Edvardsson, KarinKarolinska Institutet (author)
Haldosén, Lars-ArneKarolinska Institutet (author)
Gustafsson, Jan-AkeKarolinska Institutet (author)
Karolinska InstitutetKarolinska Institutet, Sweden (creator_code:org_t)

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In:Breast cancer research : BCR: Springer Science and Business Media LLC11:3, s. R26-1465-542X

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