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Polyphosphoester-st...
Polyphosphoester-stabilized cubosomes encapsulating a Ru(II) complex for the photodynamic treatment of lung adenocarcinoma
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- Casula, Luca (författare)
- University of Cagliari
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- Elena Giacomazzo, Gina (författare)
- University of Florence
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- Conti, Luca (författare)
- University of Florence
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- Fornasier, Marco (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Center for Colloid and Surface Science (CSGI)
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- Manca, Benedetto (författare)
- University of Cagliari
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- Schlich, Michele (författare)
- University of Cagliari
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- Sinico, Chiara (författare)
- University of Cagliari
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- Rheinberger, Timo (författare)
- University of Twente
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- Wurm, Frederik R. (författare)
- University of Twente
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- Giorgi, Claudia (författare)
- University of Florence
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- Murgia, Sergio (författare)
- University of Cagliari
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(creator_code:org_t)
- 2024
- 2024
- Engelska 12 s.
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Ingår i: Journal of Colloid and Interface Science. - 0021-9797. ; 670, s. 234-245
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The clinical translation of photosensitizers based on ruthenium(II) polypyridyl complexes (RPCs) in photodynamic therapy of cancer faces several challenges. To address these limitations, we conducted an investigation to assess the potential of a cubosome formulation stabilized in water against coalescence utilizing a polyphosphoester analog of Pluronic F127 as a stabilizer and loaded with newly synthesized RPC-based photosensitizer [Ru(dppn)2(bpy-morph)](PF6)2 (bpy-morph = 2,2′-bipyridine-4,4′-diylbis(morpholinomethanone)), PS-Ru. The photophysical characterization of PS-Ru revealed its robust capacity to induce the formation of singlet oxygen (1O2). Furthermore, the physicochemical analysis of the PS-Ru-loaded cubosomes dispersion demonstrated that the encapsulation of the photosensitizer within the nanoparticles did not disrupt the three-dimensional arrangement of the lipid bilayer. The biological tests showed that PS-Ru-loaded cubosomes exhibited significant phototoxic activity when exposed to the light source, in stark contrast to empty cubosomes and to the same formulation without irradiation. This promising outcome suggests the potential of the formulation in overcoming the drawbacks associated with the clinical use of RPCs in photodynamic therapy for anticancer treatments.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Cancer
- Drug delivery
- Liquid crystalline nanoparticles
- Photodynamic therapy
- ruthenium(II) polypyridyl complexes
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Casula, Luca
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Elena Giacomazzo ...
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Conti, Luca
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Fornasier, Marco
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Manca, Benedetto
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Schlich, Michele
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visa fler...
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Sinico, Chiara
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Rheinberger, Tim ...
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Wurm, Frederik R ...
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Giorgi, Claudia
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Murgia, Sergio
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visa färre...
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