Sökning: WFRF:(Ulfgren Ann Kristin) >
Increased expressio...
-
Marchini, GiovannaKarolinska Institutet
(författare)
Increased expression of HMGB-1 in the skin lesions of erythema toxicum
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
-
Wiley,2007
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:kth-17138
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-17138URI
-
https://doi.org/10.1111/j.1525-1470.2007.00498.xDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:116281577URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
QC 20100525
-
At birth, commensal microbes penetrate into the skin of the human newborn, eliciting an acute rash, erythema toxicumn neonatorum. Histologically, the rash is characterized by an upregulation of proinflammatory activity and a local recruitment of immunocytes, including macrophages. High mobility group box chromosomal protein 1, a nuclear and cytosolic protein, is also a pro-inflammatory cytokine released by macrophages in response to microbial stimulation. Here, we reasoned that macrophages but also keratinocytes might upregulate this protein in response to the first colonization and that high mobility group box chromosomal protein 1 might play a role as a proinflammatory mediator in the development and progression of erythema toxicum. Punch biopsy specimens from 1-day-old healthy infants, seven with and four without erythema toxicum were analyzed with indirect immunohistochemistry and two different antihigh mobility group box chromosomal protein 1 antibodies, immnofluorescence, nuclear counterstaining, confocal and immunoelectron imaging. We found relocation of nuclear high mobility group box chromosomal protein 1 into the cytoplasm in keratinocytes and macrophages in erythema toxicum. Cytoplasmatic high mobility group box chromosomal protein 1 was also found in melanocytes and did neither co-locate with lysosomal-associated membrane proteins nor with melanosomes. We speculate that terrestrial adaptation triggers the induction of the endogenous danger signal high mobility group box chromosomal protein 1 in the skin of the newborn infant, perhaps in response to the first commensal colonization and that this signal may contribute to alert the immune system and promote a protective immune response.
Ämnesord och genrebeteckningar
-
chromatin protein hmgb1
-
newborn-infant
-
cells
-
neonatorum
-
amphoterin
-
migration
-
release
-
hmg-1
-
inflammation
-
secretion
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Hultenby, KjellKarolinska Institutet
(författare)
-
Nelson, Annika
(författare)
-
Yektaei-Karin, ElharnKarolinska Institutet
(författare)
-
Stabi, Berit
(författare)
-
Lonne-Rahm, Solbritt
(författare)
-
Ulfgren, Ann-Kristin
(författare)
-
Brismar, HjalmarKarolinska Institutet,KTH,Cellens fysik(Swepub:kth)u1232ew5
(författare)
-
Karolinska InstitutetCellens fysik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Pediatric dermatology: Wiley24:5, s. 474-4820736-80461525-1470
Internetlänk
Hitta via bibliotek
Till lärosätets databas