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Sökning: WFRF:(BOGDANOVIC G) > (2015-2019) > Neuropeptide S- and...

  • Adori, CsabaKarolinska Institutet (författare)

Neuropeptide S- and Neuropeptide S receptor-expressing neuron populations in the human pons

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2015-09-25
  • Frontiers Media SA,2015
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-176363
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176363URI
  • https://doi.org/10.3389/fnana.2015.00126DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132145689URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20151104
  • Neuropeptide S (NPS) is a regulatory peptide with potent pharmacological effects. In rodents, NPS is expressed in a few pontine cell clusters. Its receptor (NPSR1) is, however, widely distributed in the brain. The anxiolytic and arousal promoting effects of NPS make the NPS NPSR1 system an interesting potential drug target in mood-related disorders. However, so far possible disease-related mechanisms involving NPS have only been studied in rodents. To validate the relevance of these animal studies for i.a. drug development, we have explored the distribution of NPS-expressing neurons in the human pons using in situ hybridization and stereological methods and we compared the distribution of NPS mRNA expressing neurons in the human and rat brain. The calculation revealed a total number of 22,317 +/- 2411 NPS mRNA-positive neurons in human, bilaterally. The majority of cells (84%) were located in the parabrachial area in human: in the extension of the medial and lateral parabrachial nuclei, in the Kolliker-Fuse nucleus and around the adjacent lateral lemniscus. In human, in sharp contrast to the rodents, only very few NPS-positive cells (5%) were found close to the locus coeruleus. In addition, we identified a smaller cell cluster (11% of all NPS cells) in the pontine central gray matter both in human and rat, which has not been described previously even in rodents. We also examined the distribution of NPSR1 mRNA-expressing neurons in the human pons. These cells were mainly located in the rostral laterodorsal tegmental nucleus, the cuneiform nucleus, the microcellular tegmental nucleus region and in the periaqueductal gray. Our results show that both NPS and NPSR1 in the human pons are preferentially localized in regions of importance for integration of visceral autonomic information and emotional behavior. The reported interspecies differences must, however, be considered when looking for targets for new pharmacotherapeutical interventions.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Barde, SwapnaliKarolinska Institutet (författare)
  • Bogdanovic, NenadKarolinska Institutet (författare)
  • Uhlén, MathiasKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,Karolinska Institutet, Sweden(Swepub:kth)u1dulvmw (författare)
  • Reinscheid, Rainer R. (författare)
  • Kovacs, Gabor G. (författare)
  • Hokfelt, TomasKarolinska Institutet (författare)
  • Karolinska InstitutetProteomik och nanobioteknologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Neuroanatomy: Frontiers Media SA91662-5129

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