Sökning: WFRF:(Magnusson Yvonne 1957) >
Induction of a phar...
Induction of a pharmacologically active clonotypic B cell response directed to an immunogenic region of the human beta 2-adrenergic receptor.
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Guillet, J G (författare)
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Lengagne, R (författare)
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- Magnusson, Yvonne, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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visa fler...
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Tate, K (författare)
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Strosberg, A D (författare)
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Hoebeke, Johan (författare)
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visa färre...
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(creator_code:org_t)
- 1992
- 1992
- Engelska.
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Ingår i: Clinical and experimental immunology. - 0009-9104. ; 89:3, s. 461-7
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- It has been reported that autoantibodies against the beta 2-adrenergic receptors are involved in the pathology of allergic disorders and of Chagas' disease. Therefore, the immune response against a peptide (H26Q) corresponding to the putative second extracellular loop of the human beta 2-adrenergic receptor, which could be a target for autoantibody attack, was analysed in view of its possible immunogenicity. The free peptide induced a T cell-mediated humoral response in the context of three different murine MHC haplotypes. The T cell epitope was found to be localized in the N-terminal region of the peptide. Highly specific T helper cells were capable of stimulating B cells with the potential to generate a large antibody repertoire reactive with the loop peptide. MoAbs were screened to analyse this B cell response for antibodies potentially interfering with receptor function and a MoAb was found that impaired ligand binding to the receptor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Animals
- Antibodies
- Monoclonal
- B-Lymphocytes
- ultrastructure
- Clone Cells
- Epitopes
- Mice
- Mice
- Inbred A
- Mice
- Inbred BALB C
- Mice
- Inbred C57BL
- Receptors
- Adrenergic
- beta
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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