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Staphylococcus epid...
Staphylococcus epidermidis Isolated From Newborn Infants Express Pilus-Like Structures and Are Inhibited by the Cathelicidin-Derived Antimicrobial Peptide LL37
- Article/chapterEnglish2009
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-18625
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-18625URI
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https://doi.org/10.1203/PDR.0b013e3181a9d80cDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119135706URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20100525
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Coagulase-negative staphylococci and its subtype Staphylococcus epidermidis are major indigenous Gram-positive inhabitants of the human skin. Colonization occurs in direct connection with birth and terrestrial adaptation. This study focuses on factors that may influence skin colonization of the newborn infant that relates to the immune status of both the bacteria and the host. Skin is an effective barrier against bacteria, and this function is partly mediated by the presence of antimicrobial peptides including human cathelicidin peptide LL37. Grain-positive bacteria have been described to have adhesive pili on their surface that mediates specific attachment to the host. Here, we identify, by negative staining transmission electron microscopy (EM), two different types of pilus-like structures commonly expressed on S. epidermidis isolated from newborn infants. We also show that the cathelicidin antimicrobial peptide LL37, constitutively expressed in the skin barrier of the newborn, significantly inhibited growth of S. epidermidis indicating its importance for the ecological stability of the skin microbiota. Further studies are required to elucidate molecular mechanisms of host-microbe interactions, both for the maintenance of a mutually beneficial homeostatic relationship and for the protection of self when it results in overt disease. (Pediatr Res 66: 174-178, 2009)
Subject headings and genre
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coagulase-negative staphylococci
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erythema toxicum neonatorum
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fibrinogen-binding protein
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skin
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strains
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ll-37
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accumulation
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infections
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adherence
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bacteria
Added entries (persons, corporate bodies, meetings, titles ...)
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Hultenby, KjellKarolinska Institutet
(author)
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Hell, EvaKarolinska Institutet
(author)
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Riedel, Hilde M.
(author)
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Brismar, HjalmarKarolinska Institutet,KTH,Cellens fysik(Swepub:kth)u1232ew5
(author)
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Flock, Jan-IngmarKarolinska Institutet
(author)
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Lundahl, JoachimKarolinska Institutet
(author)
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Giske, Christian G.Karolinska Institutet
(author)
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Marchini, GiovannaKarolinska Institutet
(author)
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Karolinska InstitutetCellens fysik
(creator_code:org_t)
Related titles
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In:Pediatric Research66:2, s. 174-1780031-39981530-0447
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