Investigation of polymer-shelled microbubble motions in acoustophoresis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:kth-189353" > Investigation of po...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Kothapalli, Satya V. V. N.KTH,Medicinsk teknik (author)

Investigation of polymer-shelled microbubble motions in acoustophoresis

Article/chapterEnglish2016

Publisher, publication year, extent ...

Elsevier,2016
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:kth-189353
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-189353URI
https://doi.org/10.1016/j.ultras.2016.05.016DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:133731136URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

QC 20160707
The objective of this paper is to explore the trajectory motion of microsize (typically smaller than a red blood cell) encapsulated polymer-shelled gas bubbles propelled by radiation force in an acoustic standing-wave field and to compare the corresponding movements of solid polymer microbeads. The experimental setup consists of a microfluidic chip coupled to a piezoelectric crystal (PZT) with a resonance frequency of about 2.8 MHz. The microfluidic channel consists of a rectangular chamber with a width, w, corresponding to one wavelength of the ultrasound standing wave. It creates one full wave ultrasound of a standing-wave pattern with two pressure nodes at w/4 and 3w/4 and three antinodes at 0, w/2, and w. The peak-to-peak amplitude of the electrical potential over the PZT was varied between 1 and 10 V. The study is limited to no-flow condition. From Gor'kov's potential equation, the acoustic contrast factor, Phi, for the polymer-shelled microbubbles was calculated to about -60.7. Experimental results demonstrate that the polymer-shelled microbubbles are translated and accumulated at the pressure antinode planes. This trajectory motion of polymer-shelled microbubbles toward the pressure antinode plane is similar to what has been described for other acoustic contrast particles with a negative Phi. First, primary radiation forces dragged the polymer-shelled microbubbles into proximity with each other at the pressure antinode planes. Then, primary and secondary radiation forces caused them to quickly aggregate at different spots along the channel. The relocation time for polymer-shelled microbubbles was 40 times shorter than that for polymer microbeads, and in contrast to polymer microbeads, the polymer-shelled microbubbles were actuated even at driving voltages (proportional to radiation forces) as low as 1 V. In short, the polymer-shelled microbubbles demonstrate the behavior attributed to the negative acoustic contrast factor particles and thus can be trapped at the antinode plane and thereby separated from particles having a positive acoustic contrast factor, such as for example solid particles and cells. This phenomenon could be utilized in exploring future applications, such as bioassay, bioaffinity, and cell interaction studies in vitro in a well-controlled environment.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Acoustophoresis
Ultrasound contrast agent
Radiation force
Ultrasound standing wave
Acoustic contrast factor

Added entries (persons, corporate bodies, meetings, titles ...)

Wiklund, MartinKTH,Biomedicinsk fysik och röntgenfysik(Swepub:kth)u1rillco (author)
Janerot-Sjöberg, BirgittaKarolinska Institutet,KTH,Medicinsk teknik,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden(Swepub:kth)u1pw7lam (author)
Paradossi, Gaio (author)
Grishenkov, DmitryKarolinska Institutet,KTH,Medicinsk teknik,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden(Swepub:kth)u1b9avjc (author)
KTHMedicinsk teknik (creator_code:org_t)

Related titles

In:Ultrasonics: Elsevier70, s. 275-2830041-624X1874-9968

Internet link

Find in a library

Ultrasonics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Kothapalli, Saty ...; Wiklund, Martin; Janerot-Sjöberg, ...; Paradossi, Gaio; Grishenkov, Dmit ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

Articles in the publication: Ultrasonics

By the university: Royal Institute of Technology; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se