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Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

Ståhl, Patrik, Dr. (author)
KTH Royal Institute of Technology,Karolinska Institute,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden.;KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Salmén, Fredrik (author)
KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Vickovic, Sanja (author)
KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
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Lundmark, Anna (author)
KTH Royal Institute of Technology,Karolinska Institute,Karolinska Institutet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.;Karolinska Inst, Div Periodontol, Dept Dent Med, SE-14104 Huddinge, Sweden.
Fernandez Navarro, Jose (author)
KTH Royal Institute of Technology,Karolinska Institute,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden.;KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Magnusson, Jens (author)
Karolinska Institute,Karolinska Institutet
Giacomello, Stefania (author)
KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Asp, Michaela (author)
Karolinska Institute,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Orzechowski Westholm, Jakub (author)
Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Box 1031, SE-17121 Solna, Sweden.
Huss, Mikael (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Box 1031, SE-17121 Solna, Sweden.
Mollbrink, Annelie (author)
KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Linnarsson, Sten (author)
Karolinska Institute,Karolinska Institutet
Codeluppi, Simone (author)
Karolinska Institute,Karolinska Institutet
Borg, Åke (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Pontén, Fredrik (author)
Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi
Costea, Paul Igor (author)
KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Sahlén, Pelin (author)
KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Mulder, Jan (author)
Karolinska Institute,Karolinska Institutet
Bergmann, Olaf (author)
Karolinska Institute,Karolinska Institutet
Lundeberg, Joakim (author)
KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, SE-10691 Stockholm, Sweden.
Frisen, Jonas (author)
Karolinska Institute,Karolinska Institutet
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 (creator_code:org_t)
AMER ASSOC ADVANCEMENT SCIENCE, 2016
2016
English.
In: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 353:6294, s. 78-82
Related links:
http://dx.doi.org/10...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
http://kipublication...
https://lup.lub.lu.s...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Analysis of the pattern of proteins or messenger RNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics. This typically involves the visualization of a few proteins or expressed genes at a time. We have devised a strategy, which we call "spatial transcriptomics," that allows visualization and quantitative analysis of the transcriptome with spatial resolution in individual tissue sections. By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, we demonstrate high-quality RNA-sequencing data with maintained two-dimensional positional information from the mouse brain and human breast cancer. Spatial transcriptomics provides quantitative gene expression data and visualization of the distribution of mRNAs within tissue sections and enables novel types of bioinformatics analyses, valuable in research and diagnostics.

Subject headings

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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