Search: id:"swepub:oai:DiVA.org:kth-18996" >
Simple cellular and...
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Kozlov, AlexanderKarolinska Institutet,KTH,Beräkningsbiologi, CB
(author)
Simple cellular and network control principles govern complex patterns of motor behavior
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-11-24
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Proceedings of the National Academy of Sciences,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-18996
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-18996URI
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https://doi.org/10.1073/pnas.0906722106DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119688272URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20100525
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The vertebrate central nervous system is organized in modules that independently execute sophisticated tasks. Such modules are flexibly controlled and operate with a considerable degree of autonomy. One example is locomotion generated by spinal central pattern generator networks (CPGs) that shape the detailed motor output. The level of activity is controlled from brainstem locomotor command centers, which in turn, are under the control of the basal ganglia. By using a biophysically detailed, full-scale computational model of the lamprey CPG (10,000 neurons) and its brainstem/forebrain control, we demonstrate general control principles that can adapt the network to different demands. Forward or backward locomotion and steering can be flexibly controlled by local synaptic effects limited to only the very rostral part of the network. Variability in response properties within each neuronal population is an essential feature and assures a constant phase delay along the cord for different locomotor speeds.
Subject headings and genre
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basal ganglia
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brainstem
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computational model
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lamprey
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spinal CPG
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spinal locomotor network
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intersegmental coordination
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fictive
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locomotion
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coupled oscillators
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rhythm generation
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lamprey
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mechanisms
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neurons
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cord
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motoneurons
Added entries (persons, corporate bodies, meetings, titles ...)
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Huss, MikaelKTH,Beräkningsbiologi, CB(Swepub:kth)u18l1u4o
(author)
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Lansner, AndersKTH,Beräkningsbiologi, CB(Swepub:kth)u12s8cr8
(author)
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Hellgren Kotaleski, JeanetteKarolinska Institutet,KTH,Beräkningsbiologi, CB(Swepub:kth)u13pnwqn
(author)
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Grillner, StenKarolinska Institutet
(author)
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KTHBeräkningsbiologi, CB
(creator_code:org_t)
Related titles
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In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences106:47, s. 20027-200320027-84241091-6490
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