Aqueous Synthesis and Fluorescence-Imaging Application of CdTe/ZnSe Core/Shell Quantum Dots with High Stability and Low Cytotoxicity

• CdTe/ZnSe core/shell quantum dots were directly synthesized in an aqueous condition by heating a mixed solution of ZnCl2, NaHSe and CdTe QDs in the presence of mercaptosuccinic acid as a stabilizer. By controlling the size and composition, the CdTe/ZnSe QDs with emission wavelength ranging from 540 to 630 nm, high quantum yield (44%) and narrow full width at half maximum (FWHM) could be obtained. Characterization results with HRTEM, XRD and EDX have shown that the synthesized CdTe/ZnSe ON have good monodispersity and a nice crystal structure, and exhibited better stability and less cytotoxicity as compared with CdTe QDs. Furthermore, luminescent QD-IgG bioprobes were produced to detect the breast cancer marker Her2 on the surface of fixed MCF-7 cancer cells for their optical imaging.

Subject headings

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Materialteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Materials Engineering (hsv//eng)

NATURVETENSKAP  -- Fysik -- Den kondenserade materiens fysik (hsv//swe)

NATURAL SCIENCES  -- Physical Sciences -- Condensed Matter Physics (hsv//eng)

Keyword

Optical Imaging

Quantum Dots

Aqueous Synthesis

Cytotoxicity

Stability

Fluorescence

Core-Shell Structure

cdte nanocrystals

in-vivo

room-temperature

size series

photoluminescence

photostability

nanoparticles

therapy

vitro

Chemistry

Kemi

Materials science

Teknisk materialvetenskap

Condensed matter physics

Kondenserade materiens fysik

Publication and Content Type

ref (subject category)

art (subject category)