Shear Wave Elastography Quantifies Stiffness in Ex Vivo Porcine Artery with Stiffened Arterial Region

• Five small porcine aortas were used as a human carotid artery model, and their stiffness was estimatedusing shear wave elastography (SWE) in the arterial wall and a stiffened artery region mimicking a stiff plaque. Tooptimize the SWE settings, shear wave bandwidth was measured with respect to acoustic radiation force pushlength and number of compounded angles used for motion detection with plane wave imaging. The mean arterialwall and simulated plaque shear moduli varied from 41 ± 5 to 97 ± 10 kPa and from 86 ± 13 to 174 ± 35 kPa, respectively,over the pressure range 20–120 mmHg. The results revealed that a minimum bandwidth of approximately1500 Hz is necessary for consistent shear modulus estimates, and a high pulse repetition frequency using no imagecompounding is more important than a lower pulse repetition frequency with better image quality when estimatingarterial wall and plaque stiffness using SWE.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Image Processing (hsv//eng)

Nyckelord

Artery

Arteriosclerosis

Atherosclerosis

Elasticity

Ex vivo

Plaque

Phase velocity

Shear wave elastography

Ultrasound

Medical Technology

Medicinsk teknologi

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