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  • Gloriam, David E. (author)

A Community Standard Format for the Representation of Protein Affinity Reagents

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-19307
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-19307URI
  • https://doi.org/10.1074/mcp.M900185-MCP200DOI
  • https://lup.lub.lu.se/record/1588255URI
  • https://res.slu.se/id/publ/61298URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147448URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20110114
  • Protein affinity reagents (PARs), most commonly antibodies, are essential reagents for protein characterization in basic research, biotechnology, and diagnostics as well as the fastest growing class of therapeutics. Large numbers of PARs are available commercially; however, their quality is often uncertain. In addition, currently available PARs cover only a fraction of the human proteome, and their cost is prohibitive for proteome scale applications. This situation has triggered several initiatives involving large scale generation and validation of antibodies, for example the Swedish Human Protein Atlas and the German Antibody Factory. Antibodies targeting specific subproteomes are being pursued by members of Human Proteome Organisation (plasma and liver proteome projects) and the United States National Cancer Institute (cancer-associated antigens). ProteomeBinders, a European consortium, aims to set up a resource of consistently quality-controlled protein-binding reagents for the whole human proteome. An ultimate PAR database resource would allow consumers to visit one online warehouse and find all available affinity reagents from different providers together with documentation that facilitates easy comparison of their cost and quality. However, in contrast to, for example, nucleotide databases among which data are synchronized between the major data providers, current PAR producers, quality control centers, and commercial companies all use incompatible formats, hindering data exchange. Here we propose Proteomics Standards Initiative (PSI)-PAR as a global community standard format for the representation and exchange of protein affinity reagent data. The PSI-PAR format is maintained by the Human Proteome Organisation PSI and was developed within the context of ProteomeBinders by building on a mature proteomics standard format, PSI-molecular interaction, which is a widely accepted and established community standard for molecular interaction data. Further information and documentation are available on the PSI-PAR web site. Molecular & Cellular Proteomics 9: 1-10, 2010.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Orchard, Sandra (author)
  • Bertinetti, Daniela (author)
  • Björling, ErikKTH,Albanova VinnExcellence Center for Protein Technology, ProNova(Swepub:kth)u15l719e (author)
  • Bongcam Rudloff, ErikUppsala universitet,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Centrum för bioinformatik(Swepub:uu)erikbr (author)
  • Borrebaeck, CarlLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)immt-cbo (author)
  • Bourbeillon, Julie (author)
  • Bradbury, Andrew R. M. (author)
  • de Daruvar, Antoine (author)
  • Duebel, Stefan (author)
  • Frank, Ronald (author)
  • Gibson, Toby J. (author)
  • Gold, Larry (author)
  • Haslam, Niall (author)
  • Herberg, Friedrich W. (author)
  • Hiltke, Tara (author)
  • Hoheisel, Joerg D. (author)
  • Kerrien, Samuel (author)
  • Koegl, Manfred (author)
  • Konthur, Zoltan (author)
  • Korn, Bernhard (author)
  • Landegren, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfland (author)
  • Montecchi-Palazzi, Luisa (author)
  • Palcy, Sandrine (author)
  • Rodriguez, Henry (author)
  • Schweinsberg, Sonja (author)
  • Sievert, Volker (author)
  • Stoevesandt, Oda (author)
  • Taussig, Michael J. (author)
  • Ueffing, Marius (author)
  • Uhlén, MathiasKTH,Proteomik(Swepub:kth)u1dulvmw (author)
  • van der Maarel, Silvere (author)
  • Wingren, ChristerLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)immt-cwi (author)
  • Woollard, Peter (author)
  • Sherman, David J. (author)
  • Hermjakob, Henning (author)
  • KTHAlbanova VinnExcellence Center for Protein Technology, ProNova (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Related titles

  • In:Molecular & Cellular Proteomics9:1, s. 1-101535-94761535-9484

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