id:"swepub:oai:DiVA.org:kth-195193"
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- Debevec, T. (författare)
Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
- Academic Press,2016
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Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:kth-195193
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-195193URI
- https://doi.org/10.1016/j.appet.2016.07.005DOI
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- Språk:engelska
- Sammanfattning på:engelska
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Anmärkningar
- QC 20161202
- Environmental hypoxia and inactivity have both been shown to modulate appetite. To elucidate the independent and combined effects of hypoxia and bed rest-induced inactivity on appetite-related hormones and subjective appetite, eleven healthy, non-obese males underwent three experimental interventions in a cross-over and randomized fashion: 1) Hypoxic confinement combined with daily moderate-intensity exercise (HAMB, FiO2 = 0.141 ± 0.004; PiO2 = 90.0 ± 0.4 mmHg) 2) Bed rest in normoxia (NBR, FiO2 = 0.209; PiO2 = 133.1 ± 0.3 mmHg) and 3) Bed rest in hypoxia (HBR, FiO2 = 0.141 ± 0.004; PiO2 = 90.0 ± 0.4 mmHg). A mixed-meal tolerance test (MTT), followed by an ad libitum meal were performed before (Pre) and after 16-days (Post) of each intervention. Composite satiety scores (CSS) during the MTT were calculated from visual analogue scores, while fasting and postprandial concentrations of total ghrelin, peptide YY (PYY), glucagon-like peptide-1 (GLP-1) and leptin were quantified from arterialized-venous samples. Postprandial CSS were significantly lower at Post compared to Pre in NBR only (P < 0.05) with no differences observed in ad libitum meal intakes. Postprandial concentrations and incremental area under the curve (AUC) for total ghrelin and PYY were unchanged following all interventions. Postprandial GLP-1 concentrations were only reduced at Post following HBR (P < 0.05) with resulting AUC changes being significantly lower compared to HAMB (P < 0.01). Fasting leptin was reduced following HAMB (P < 0.05) with no changes observed following NBR and HBR. These findings suggest that independently, 16-day of simulated altitude exposure (∼4000 m) and bed rest-induced inactivity do not significantly alter subjective appetite or ad libitum intakes. The measured appetite-related hormones following both HAMB and HBR point to a situation of hypoxia-induced appetite stimulation, although this did not reflect in higher ad libitum intakes. Clinical Trial Registration Number: NCT02293772.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng
- Appetite regulation
- Bed rest
- High altitude anorexia
- Hypoxemia
- Inactivity
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Simpson, E. J. (författare)
- Mekjavic, I. B. (författare)
- Eiken, OlaKTH,Omgivningsfysiologi,Centrum för flyg- och rymdfysiologi, SAPC(Swepub:kth)u1fcwvxl (författare)
- Macdonald, I. A. (författare)
- KTHOmgivningsfysiologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Appetite: Academic Press107, s. 28-370195-66631095-8304
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- Debevec, T.
- Simpson, E. J.
- Mekjavic, I. B.
- Eiken, Ola
- Macdonald, I. A.
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