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  • Backman, HelenaUmeå universitet,Avdelningen för hållbar hälsa,Section for Sustainable Health, Umeå University, Umeå, Sweden (author)

Lung function trajectories and associated mortality among adults with and without airway obstruction

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Thoracic Society,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-212976
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212976URI
  • https://doi.org/10.1164/rccm.202211-2166ocDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-100276URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Validerad;2023;Nivå 2;2023-12-04 (hanlid);Funder: Swedish Respiratory Society; VISARE NORR Fund Northern County Councils Regional Federation
  • Rationale: Spirometry is essential for diagnosis and assessment of prognosis in COPD.Objectives: To identify FEV1 trajectories and their determinants, based on annual spirometry measurements among individuals with and without airway obstruction. Furthermore, to assess mortality in relation to trajectories.Methods: In 2002-04, individuals with airway obstruction (AO) (FEV1/VC<0.70, n=993) and age- and sex-matched non-obstructive (NO) referents were recruited from population-based cohorts. Annual spirometries until 2014 were utilized in joint-survival Latent Class Mixed Models to identify lung function trajectories. Mortality data were collected during 15 years of follow-up.Results: Three trajectories were identified among the AO-cases and two among the NO referents. Trajectory membership was driven by baseline FEV1%predicted (%pred) in both groups and additionaly, pack-years in AO and current smoking in NO. Longitudinal FEV1%pred level depended on baseline FEV1%pred, pack-years and obesity. The trajectories were distributed: 79.6% T1AO FEV1-high with normal decline, 12.8% T2AO FEV1-high with rapid decline, and 7.7% T3AO FEV1-low with normal decline (mean 27, 72 and 26 mL/year) among AO-individuals, and 96.7% T1NO FEV1-high with normal decline and 3.3% T2NO FEV1-high with rapid decline (mean 34 and 173 mL/year) among referents. Hazard for death was increased for T2AO (HR1.56) and T3AO (HR3.45) vs. T1AO, and for T2NO (HR2.99) vs. T1NO.Conclusions: Three different FEV1 trajectories were identified among those with airway obstruction and two among the referents, with different outcomes in terms of FEV1-decline and mortality. The FEV1 trajectories among airway obstructive and the relationship between low FVC and trajectory outcome are of particular clinical interest.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Blomberg, Anders,1961-Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)anbl0001 (author)
  • Lundquist, Anders,1978-Umeå universitet,Statistik,Department of Statistics, Umeå School of Business, Economics and Statistics (USBE), Umeå University, Umeå, Sweden(Swepub:umu)anslst97 (author)
  • Strandkvist, ViktorLuleå tekniska universitet,Hälsa, medicin och rehabilitering(Swepub:ltu)joikvh (author)
  • Sawalha, Sami,1975-Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)sasa0131 (author)
  • Nilsson, Ulf,1974-Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)ulni0011 (author)
  • Eriksson Ström, Jonas,1977-Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)joer0101 (author)
  • Hedman, Linnea,1979-Umeå universitet,Avdelningen för hållbar hälsa,Section for Sustainable Health, Umeå University, Umeå, Sweden(Swepub:umu)evli0029 (author)
  • Stridsman, CarolineUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)cast0052 (author)
  • Rönmark, EvaUmeå universitet,Avdelningen för hållbar hälsa,Section for Sustainable Health, Umeå University, Umeå, Sweden(Swepub:umu)evra0004 (author)
  • Lindberg, AnneUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)anelig02 (author)
  • Umeå universitetAvdelningen för hållbar hälsa (creator_code:org_t)

Related titles

  • In:American Journal of Respiratory and Critical Care Medicine: American Thoracic Society208:10, s. 1063-10741073-449X1535-4970

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