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Self-assembly and h...
Self-assembly and hybridization mechanisms of DNA with cationic polythiophene
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- Rubio-Magnieto, Jenifer (författare)
- Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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- Gebremedhn Azene, Elias (författare)
- Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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- Knoops, Jeremie (författare)
- Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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- Knippenberg, Stefan (författare)
- KTH,Teoretisk kemi och biologi,University of Mons, Belgium
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- Delcourt, Cecile (författare)
- Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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- Thomas, Amandine (författare)
- Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite ́ de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
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- Richeter, Sebastien (författare)
- Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite ́ de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
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- Mehdi, Ahmad (författare)
- Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite ́ de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
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- Dubois, Philippe (författare)
- Laboratory for Polymeric and Composites Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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- Lazzaroni, Roberto (författare)
- Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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- Beljonne, David (författare)
- Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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- Clement, Sebastien (författare)
- Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
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- Surin, Mathieu (författare)
- Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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(creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: Soft Matter. - : Royal Society of Chemistry. - 1744-683X .- 1744-6848. ; 11:2, s. 6460-6471
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The combination of DNA and pi-conjugated polyelectrolytes (CPEs) represents a promising approach to develop DNA hybridization biosensors, with potential applications for instance in the detection of DNA lesions and single-nucleotide polymorphisms. Here we exploit the remarkable optical properties of a cationic poly[3-(6'-(trimethylphosphonium)hexyl)thiophene-2,5-diyl] (CPT) to decipher the self-assembly of DNA and CPT. The ssDNA/ CPT complexes have chiroptical signatures in the CPT absorption region that are strongly dependent on the DNA sequence, which we relate to differences in supramolecular interactions between the thiophene monomers and the various nucleobases. By studying DNA-DNA hybridization and melting processes on preformed ssDNA/ CPT complexes, we observe sequence-dependent mechanisms that can yield DNA-condensed aggregates. Heating-cooling cycles show that non-equilibrium mixtures can form, noticeably depending on the working sequence of the hybridization experiment. These results are of high importance for the use of pi-conjugated polyelectrolytes in DNA hybridization biosensors and in polyplexes.
Ämnesord
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Nyckelord
- Soluble Conjugated Polymers
- Nucleic-Acid Probes
- Optical-Detection
- Polyelectrolytes
- Sequence
- Fluorescence
- Proteins
- Binding
- Condensation
- Complexes
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Rubio-Magnieto, ...
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Gebremedhn Azene ...
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Knoops, Jeremie
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Knippenberg, Ste ...
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Delcourt, Cecile
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Thomas, Amandine
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visa fler...
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Richeter, Sebast ...
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Mehdi, Ahmad
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Dubois, Philippe
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Lazzaroni, Rober ...
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Beljonne, David
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Clement, Sebasti ...
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Surin, Mathieu
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Annan kemi
- Artiklar i publikationen
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Soft Matter
- Av lärosätet
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Kungliga Tekniska Högskolan