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A simple polyol-fre...
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Ahrén, MariaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
(författare)
A simple polyol-free synthesis route to Gd 2O 3 nanoparticles for MRI applications : An experimental and theoretical study
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-07-10
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Springer,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-198742
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-198742URI
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https://doi.org/10.1007/s11051-012-1006-2DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-81505URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20240112
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Funding Agencies|VINNOVA|2008-03011|Centre in Nanoscience and Technology at LiTH (CeNano)||Swedish research council|621-2010-5014|SERC (Swedish e-Science Research Center)||
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Chelated gadolinium ions, e.g., Gd-DTPA, are today used clinically as contrast agents for magnetic resonance imaging (MRI). An attractive alternative contrast agent is composed of gadolinium oxide nanoparticles as they have shown to provide enhanced contrast and, in principle, more straightforward molecular capping possibilities. In this study, we report a new, simple, and polyol-free way of synthesizing 4-5-nm-sized Gd 2O 3 nanoparticles at room temperature, with high stability and water solubility. The nanoparticles induce high-proton relaxivity compared to Gd-DTPA showing r 1 and r 2 values almost as high as those for free Gd 3+ ions in water. The Gd 2O 3 nanoparticles are capped with acetate and carbonate groups, as shown with infrared spectroscopy, near-edge X-ray absorption spectroscopy, X-ray photoelectron spectroscopy and combined thermogravimetric and mass spectroscopy analysis. Interpretation of infrared spectroscopy data is corroborated by extensive quantum chemical calculations. This nanomaterial is easily prepared and has promising properties to function as a core in a future contrast agent for MRI.
Ämnesord och genrebeteckningar
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NATURVETENSKAP Kemi Teoretisk kemi hsv//swe
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NATURAL SCIENCES Chemical Sciences Theoretical Chemistry hsv//eng
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Gadolinium oxide
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IR
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Relaxivity
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Synthesis
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Toxicity
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XPS
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Carbonate group
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Contrast agent
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Enhanced contrast
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Gadolinium ions
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Gd-DTPA
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High stability
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Mass spectroscopy
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Nanomaterial
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Near-edge x-ray absorption
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Quantum chemical calculations
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Room temperature
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Synthesis route
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Theoretical study
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Thermogravimetric
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Water solubilities
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X-ray photoelectrons
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Alcohols
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Infrared spectroscopy
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Iridium
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Magnetic resonance imaging
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Mass spectrometry
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Nanoparticles
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Photoelectrons
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Quantum chemistry
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Synthesis (chemical)
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Thermogravimetric analysis
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X ray absorption spectroscopy
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X ray photoelectron spectroscopy
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Gadolinium
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gadolinium chloride
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gadolinium oxide nanoparticle
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gadolinium pentetate
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nanoparticle
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nuclear magnetic resonance imaging agent
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polyol
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unclassified drug
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article
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chemical composition
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drug synthesis
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light scattering
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molecular stability
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nuclear magnetic resonance imaging
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particle size
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priority journal
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thermogravimetry
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transmission electron microscopy
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X ray diffraction
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TECHNOLOGY
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kauczor, JoannaLinköpings universitet,Beräkningsfysik,Tekniska högskolan(Swepub:liu)joaka07
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Norman, PatrickLinköpings universitet,Beräkningsfysik,Tekniska högskolan(Swepub:liu)patno81
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Käll, Per-OlovLinköpings universitet,Fysikalisk Kemi,Tekniska högskolan(Swepub:liu)perka28
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Uvdal, KajsaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)kajuv09
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Linköpings universitetMolekylär ytfysik och nanovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of nanoparticle research: Springer14:81388-07641572-896X
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