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Autoantibody target...
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Häggmark-Månberg, AnnaKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab
(author)
Autoantibody targets in vaccine-associated narcolepsy
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-05-20
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Taylor & Francis,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-198898
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-198898URI
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https://doi.org/10.1080/08916934.2016.1183655DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134650347URI
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https://lup.lub.lu.se/record/097f71cd-08ca-43cd-8385-7cf8f9a4e08aURI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20170109
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Narcolepsy is a chronic sleep disorder with a yet unknown cause, but the specific loss of hypocretin-producing neurons together with a strong human leukocyte antigen (HLA) association has led to the hypothesis that autoimmune mechanisms might be involved. Here, we describe an extensive effort to profile autoimmunity repertoires in serum with the aim to find disease-related autoantigens. Initially, 57 serum samples from vaccine-associated and sporadic narcolepsy patients and controls were screened for IgG reactivity towards 10 846 fragments of human proteins using planar microarrays. The discovered differential reactivities were verified on suspension bead arrays in the same sample collection followed by further investigation of 14 antigens in 176 independent samples, including 57 narcolepsy patients. Among these 14 antigens, methyltransferase-like 22 (METTL22) and 5'-nucleotidase cytosolic IA (NT5C1A) were recognized at a higher frequency in narcolepsy patients of both sample sets. Upon sequence analysis of the 14 proteins, polymerase family, member 3 (PARP3), acyl-CoA-binding domain containing 7 (ARID4B), glutaminase 2 (GLS2) and cyclin-dependent kinase-like 1 (CDKL1) were found to contain amino acid sequences with homology to proteins found in the H1N1 vaccine. These findings could become useful elements of further clinical assays that aim towards a better phenotypic understanding of narcolepsy and its triggers.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Zandian, ArashKTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u11qiehv
(author)
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Forsström, BjörnKTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u11i5nju
(author)
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Khademi, MohsenKarolinska Institutet
(author)
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Bomfim, Izaura LimaKarolinska Institutet
(author)
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Hellström, CeciliaKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1doy1fn
(author)
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Arnheim-Dahlström, LisenKarolinska Institutet
(author)
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Hallböök, ToveLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pedi-tha
(author)
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Darin, Niklas
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Lundberg, Ingrid E.Karolinska Institutet,Karolinska University Hospital
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Uhlén, MathiasKTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw
(author)
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Partinen, MarkkuUniversity of Helsinki
(author)
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Schwenk, Jochen M.KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1h7wtme
(author)
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Olsson, TomasKarolinska Institutet
(author)
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Nilsson, PeterKTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ws88sk
(author)
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KTHScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
Related titles
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In:Autoimmunity: Taylor & Francis49:6, s. 421-4330891-69341607-842X
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Häggmark-Månberg ...
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Zandian, Arash
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Forsström, Björn
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Khademi, Mohsen
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Bomfim, Izaura L ...
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Hellström, Cecil ...
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Arnheim-Dahlströ ...
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Hallböök, Tove
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Darin, Niklas
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Lundberg, Ingrid ...
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Uhlén, Mathias
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Partinen, Markku
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Schwenk, Jochen ...
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Olsson, Tomas
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Nilsson, Peter
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Autoimmunity
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Royal Institute of Technology
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Karolinska Institutet
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Lund University