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  • Romanov, Roman A. (author)

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-12-19
  • Nature Publishing Group,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-203160
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-203160URI
  • https://doi.org/10.1038/nn.4462DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135145675URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20170315
  • The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron identity. Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S+ neurons of the suprachiasmatic nucleus. These neuroendocrine dopamine cells may contribute to the dopaminergic inhibition of prolactin secretion diurnally, as their neuromedin S+ inputs originate from neurons expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a circadian fashion. Overall, our catalog of neuronal subclasses provides new understanding of. hypothalamic organization and function.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zeisel, AmitKarolinska Institutet (author)
  • Bakker, JoanneKarolinska Institutet (author)
  • Girach, Fatima (author)
  • Hellysaz, Arash (author)
  • Tomer, Raju (author)
  • Alpar, Alan (author)
  • Mulder, JanKarolinska Institutet (author)
  • Clotman, Frederic (author)
  • Keimpema, Erik (author)
  • Hsueh, Brian (author)
  • Crow, Ailey K. (author)
  • Martens, Henrik (author)
  • Schwindling, Christian (author)
  • Calvigioni, DanielaKarolinska Institutet (author)
  • Bains, Jaideep S. (author)
  • Mate, Zoltan (author)
  • Szabo, Gabor (author)
  • Yanagawa, Yuchio (author)
  • Zhang, Ming-DongKarolinska Institutet (author)
  • Rendeiro, Andre (author)
  • Farlik, Matthias (author)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi(Swepub:kth)u1dulvmw (author)
  • Wulff, Peer (author)
  • Bock, Christoph (author)
  • Broberger, Christian (author)
  • Deisseroth, Karl (author)
  • Hokfelt, TomasKarolinska Institutet (author)
  • Linnarsson, StenKarolinska Institutet (author)
  • Horvath, Tamas L. (author)
  • Harkany, TiborKarolinska Institutet (author)
  • Karolinska InstitutetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

  • In:Nature Neuroscience: Nature Publishing Group20:2, s. 176-1881097-62561546-1726

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