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Sökning: id:"swepub:oai:DiVA.org:kth-205254" > Carbohydrate-based ...

  • Neimert-Andersson, T.Karolinska Institutet (författare)

Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy

  • Artikel/kapitelEngelska2008

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2008
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-205254
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-205254URI
  • https://doi.org/10.1111/j.1398-9995.2008.01644.xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:116813163URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20170419
  • Background: Allergen-specific immunotherapy (ASIT) is the only treatment of allergic disease that gives long-lasting relief of symptoms. However, concerns for safety and efficiency have highlighted the need for improvement of the therapy. We have previously suggested carbohydrate-based particles (CBPs) as a novel adjuvant and allergen carrier for ASIT. Our aim of this study was to evaluate the therapeutic potential of CBPs in ASIT, employing a mouse model for cat allergy. Methods: BALB/c mice were subcutaneously immunized with the recombinant (r) cat allergen Fel d 1 followed by intranasal challenge with cat dander extract (CDE). The sensitized mice were therapeutically treated with rFel d 1 covalently coupled to CBPs (CBP-rFel d 1). Airway hyper-reactivity (AHR), infiltration of leucocytes in bronchoalveolar lavage (BAL) fluid, allergen-specific serum immunoglobulin levels and in vitro splenocyte responses were evaluated. Results: Mice treated with CBP-rFel d 1 showed reduced features of allergic inflammation. They responded with (i) significantly decreased AHR and infiltration of eosinophils in BAL fluid after CDE challenge, (ii) the serum level of rFel d 1-specific IgE was reduced and the level of IgG(2)a was more pronounced after CBP-rFel d 1 treatment, and (iii) there was also a tendency of decreased allergen-specific cellular response. Conclusions: Carbohydrate-based particles are effective tools as adjuvant and allergen carriers for use in ASIT and constitutes a promising strategy to improve allergy treatment.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Thunberg, Sarah,1976-Karolinska Institutet(Swepub:kth)u1rw1xrj (författare)
  • Swedin, L.Karolinska Institutet, Sweden (författare)
  • Wiedermann, U.Medical University Vienna, Austria (författare)
  • Jacobsson-Ekman, G.Karolinska Institutet (författare)
  • Dahlen, S. -EKarolinska Institutet (författare)
  • Scheynius, A.Karolinska Institutet (författare)
  • Gronlund, H.Karolinska Institutet (författare)
  • van Hage, M.Karolinska Institutet (författare)
  • Gafvelin, G.Karolinska Institutet, Sweden (författare)
  • Karolinska InstitutetKarolinska Institutet, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Allergy. European Journal of Allergy and Clinical Immunology: John Wiley & Sons63:5, s. 518-5260105-45381398-9995

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