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Immune responses in...
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
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- Akdis, M (författare)
- SIAF, Switzerland
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- Verhagen, J (författare)
- SIAF, Switzerland
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- Taylor, A (författare)
- SIAF, Switzerland
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visa fler...
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- Karamloo, F (författare)
- SIAF, Switzerland
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- Karagiannidis, C (författare)
- SIAF, Switzerland
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- Crameri, R (författare)
- SIAF, Switzerland
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- Thunberg, Sarah, 1976- (författare)
- Karolinska Institutet
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- Deniz, G (författare)
- SIAF, Switzerland
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- Valenta, R (författare)
- SIAF, Switzerland
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- Fiebig, H (författare)
- SIAF, Switzerland
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- Kegel, C (författare)
- SIAF, Switzerland
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- Disch, R (författare)
- SIAF, Switzerland
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- Schmidt-Weber, C B (författare)
- SIAF, Switzerland
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- Blaser, K (författare)
- SIAF, Switzerland
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- Akdis, C A (författare)
- SIAF, Switzerland
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(creator_code:org_t)
- 2004-06-01
- 2004
- Engelska.
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 199:11, s. 1567-1575
- Relaterad länk:
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http://jem.rupress.o...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small fraction of the whole CD4(+) T cell repertoire and can be isolated from the peripheral blood of humans according to their cytokine profile. Freshly purified interferon-gamma-, interleukin (IL)-4-, and IL-10-producing allergen-specific CD4(+) T cells display characteristics of T helper cell (Th)1-, Th2, and T regulatory (Tr)1-like cells, respectively. Tr1 cells consistently represent the dominant subset specific for common environmental allergens in healthy individuals; in contrast, there is a high frequency of allergen-specific IL-4-secreting T cells in allergic individuals. Tr1 cells use multiple suppressive mechanisms, IL-10 and TGF-beta as secreted cytokines, and cytotoxic T lymphocyte antigen 4 and programmed death 1 as surface molecules. Healthy and allergic individuals exhibit all three allergen-specific subsets in different proportions, indicating that a change in the dominant subset may lead to allergy development or recovery. Accordingly, blocking the suppressor activity of Tr1 cells or increasing Th2 cell frequency enhances allergen-specific Th2 cell activation ex vivo. These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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- art (ämneskategori)
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- Av författaren/redakt...
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Akdis, M
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Verhagen, J
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Taylor, A
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Karamloo, F
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Karagiannidis, C
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Crameri, R
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visa fler...
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Thunberg, Sarah, ...
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Deniz, G
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Valenta, R
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Fiebig, H
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Kegel, C
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Disch, R
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Schmidt-Weber, C ...
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Blaser, K
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Akdis, C A
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visa färre...
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Kungliga Tekniska Högskolan
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Karolinska Institutet