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Discovery of circul...
Discovery of circulating proteins associated to knee radiographic osteoarthritis
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Lourido, Lucia (författare)
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- Ayoglu, Burcu (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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Fernandez-Tajes, Juan (författare)
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Oreiro, Natividad (författare)
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- Henjes, Frauke (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Hellström, Cecilia (författare)
- KTH,Proteinvetenskap
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- Schwenk, Jochen M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi
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Ruiz-Romero, Cristina (författare)
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- Nilsson, Peter (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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Blanco, Francisco J. (författare)
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visa färre...
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(creator_code:org_t)
- 2017-03-09
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for proteins that could serve as indicators for the diagnosis of radiographic knee OA. Antibody suspension bead arrays were applied to analyze serum samples from patients with OA (n = 273), control subjects (n = 76) and patients with rheumatoid arthritis (RA, n = 244). For verification, a focused bead array was built and applied to an independent set of serum samples from patients with OA (n = 188), control individuals (n = 83) and RA (n = 168) patients. A linear regression analysis adjusting for sex, age and body mass index (BMI) revealed that three proteins were significantly elevated (P < 0.05) in serum from OA patients compared to controls: C3, ITIH1 and S100A6. A panel consisting of these three proteins had an area under the curve of 0.82 for the classification of OA and control samples. Moreover, C3 and ITIH1 levels were also found to be significantly elevated (P < 0.05) in OA patients compared to RA patients. Upon validation in additional study sets, the alterations of these three candidate serum biomarker proteins could support the diagnosis of radiographic knee OA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Lourido, Lucia
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Ayoglu, Burcu
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Fernandez-Tajes, ...
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Oreiro, Nativida ...
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Henjes, Frauke
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Hellström, Cecil ...
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visa fler...
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Schwenk, Jochen ...
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Ruiz-Romero, Cri ...
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Nilsson, Peter
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Blanco, Francisc ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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