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  • Sylven, C.Karolinska Institutet (author)

Myocardial Doppler tissue velocity improves following myocardial gene therapy with VEGF-A(165) plasmid in patients with inoperable angina pectoris

  • Article/chapterEnglish2001

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2001
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-20593
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-20593URI
  • https://doi.org/10.1097/00019501-200105000-00010DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1928398URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20100525
  • Background Myocardial tissue velocity and perfusion were studied in patients with severe angina pectoris following gene therapy by intramyocardial injection of phVEGF-A(165) via thoracotomy. Plasma concentrations of VEGF-A increased postoperatively. Two months after treatment anginal status and myocardial tissue velocity improved and perfusion showed a tendency to improve. Tissue velocity imaging appears to be a sensitive, objective method for detecting changes in myocardial function following gene therapy. Objective To study effects on myocardial tissue velocity and perfusion in patients with angina pectoris following intramyocardial injection of phVEGF-A(165) via thoracotomy. Design Open label, phase I/II. Methods Six patients with Canadian Cardiovascular Society (CCS) angina pectoris functional Glass III - IV and with major defects at adenosine stress single-photon emission computerized tomography (SPECT) were studied. In addition to SPECT, coronary angiography and dobutamine stress echocardiography with tissue Doppler velocity imaging were performed before and two months after gene transfer. Results Plasma concentrations of VEGF-A increased 2 to 3 times (P < 0.04) over baseline from 2 to 14 days after injection with normalization after 4 weeks. The CCS class improved about 40%, from 3.3 +/- 0.2 to 2.0 +/- 0.3 (P < 0.02) and nitroglycerine consumption decreased 30 - 40%, from 44 +/- 17 to 15 +/- 5 tablets per week (P < 0.05). The maximal systolic myocardial tissue velocity increased in all patients about 25% (P < 0.02) but did not reach the reference range. Myocardial perfusion at SPECT improved in four of the six patients. Conclusions Anginal status, myocardial tissue velocity and perfusion can be improved by phVEGF-A(165) intramyocardial injection. Tissue velocity imaging appears to be a sensitive, objective method for detecting changes in myocardial function following gene therapy. Coron Artery Dis 12:239-243

Subject headings and genre

  • plasmid
  • VEGF
  • human
  • coronary artery disease
  • thoracotomy
  • Doppler
  • perfusion
  • echocardiography
  • disease

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sarkar, N.Karolinska Institutet (author)
  • Ruck, A.Karolinska Institutet (author)
  • Drvota, V. (author)
  • Y-Hassan, S.Karolinska Institutet (author)
  • Lind, B.Karolinska Institutet (author)
  • Nygren, A.Karolinska Institutet (author)
  • Kallner, G.Karolinska Institutet (author)
  • Blomberg, P. (author)
  • van der Linden, J.Karolinska Institutet (author)
  • Lindblom, D.Karolinska Institutet (author)
  • Brodin, Lars-Åke (author)
  • Islam, K. B. (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Coronary Artery Disease: Ovid Technologies (Wolters Kluwer Health)12:3, s. 239-2430954-69281473-5830

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