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  • Kaucka, MarketaKarolinska Institutet (author)

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Elife Sciences Publications LTD,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-207685
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207685URI
  • https://doi.org/10.7554/eLife.25902DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135707675URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320902URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20170601
  • Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zikmund, Tomas (author)
  • Tesarova, Marketa (author)
  • Gyllborg, DanielKarolinska Institutet (author)
  • Hellander, AndreasUppsala universitet,Avdelningen för beräkningsvetenskap,Tillämpad beräkningsvetenskap(Swepub:uu)andhe896 (author)
  • Jaros, JosefKarolinska Institutet (author)
  • Kaiser, Jozef (author)
  • Petersen, Julian (author)
  • Szarowska, Bara (author)
  • Newton, Phillip T.Karolinska Institutet (author)
  • Dyachuk, VyacheslavKarolinska Institutet (author)
  • li, Lei (author)
  • Qian, HongKarolinska Institutet (author)
  • Johansson, Anne-Sofie (author)
  • Mishina, Yuji (author)
  • Currie, Joshua D. (author)
  • Tanaka, Elly M. (author)
  • Erickson, Alek (author)
  • Dudley, Andrew (author)
  • Brismar, HjalmarKarolinska Institutet,KTH,Cellulär biofysik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1232ew5 (author)
  • Southam, Paul (author)
  • Coen, Enrico (author)
  • Chen, Min (author)
  • Weinstein, Lee S. (author)
  • Hampl, Ales (author)
  • Arenas, ErnestKarolinska Institutet (author)
  • Chagin, Andrei S.Karolinska Institutet (author)
  • Fried, KajKarolinska Institutet (author)
  • Adameyko, IgorKarolinska Institutet (author)
  • Currie, Josh (author)
  • Karolinska InstitutetAvdelningen för beräkningsvetenskap (creator_code:org_t)

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  • In:eLIFE: Elife Sciences Publications LTD62050-084X

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