Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies

QC 20170613
Osteoarthritis (OA) is one of the most prevalent articular diseases. The identification of proteins closely associated with the diagnosis, progression, prognosis, and treatment response is dramatically required for this pathology. In this work, differential serum protein profiles have been identified in OA and rheumatoid arthritis (RA) by antibody arrays containing 151 antibodies against 121 antigens in a cohort of 36 samples. Then the identified differential serum protein profiles have been validated in a larger cohort of 282 samples. The overall immunoreactivity is higher in the pathological situations in comparison with the controls. Several proteins have been identified as biomarker candidates for OA and RA. Most of these biomarker candidates are proteins related to inflammatory response, lipid metabolism, or bone and extracellular matrix formation, degradation, or remodeling.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
antibody arrays
serum protein profiles
osteoarthritis
rheumatoid arthritis
contact printing
noncontact printing
biomarkers

Garrido-Martin, Diego (author)
Lourido, Lucia (author)
Gonzalez-Gonzalez, Maria (author)
Diez, Paula (author)
Ruiz-Romero, Cristina (author)
Sjöberg, RonaldKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1j1wpi6 (author)
Droste, Conrad (author)
De Las Rivas, Javier (author)
Nilsson, PeterKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ws88sk (author)
Blanco, Francisco (author)
Fuentes, Manuel (author)
KTHProteomik och nanobioteknologi (creator_code:org_t)

In:Journal of Proteome Research: American Chemical Society (ACS)16:5, s. 1890-18991535-38931535-3907

By the author/editor: Sierra-Sanchez, ...; Garrido-Martin, ...; Lourido, Lucia; Gonzalez-Gonzale ...; Diez, Paula; Ruiz-Romero, Cri ...; show more...; Sjöberg, Ronald; Droste, Conrad; De Las Rivas, Ja ...; Nilsson, Peter; Blanco, Francisc ...; Fuentes, Manuel; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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