WFRF:(Daniel Weghuber)
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Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity
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- Julian, Valerie (författare)
- Univ Clermont Auvergne, INRA, Human Nutr Res Ctr CRNH,Dept Sport Med & Funct Ex, Univ Teaching Hosp Clermont Ferrand,Diet & Muscul, Clermont Ferrand, Europe, France.;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria.
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- Bergsten, Peter (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ Hosp, Children Obes Clin, Uppsala, Sweden
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- Ennequin, Gael (författare)
- Univ Clermont Auvergne, Lab Metab Adaptat Exercise Physiol & Pathol Condi, Clermont Ferrand, France.
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- Univ Clermont Auvergne, INRA, Human Nutr Res Ctr CRNH,Dept Sport Med & Funct Ex, Univ Teaching Hosp Clermont Ferrand,Diet & Muscul, Clermont Ferrand, Europe, France;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria. Institutionen för medicinsk cellbiologi (creator_code:org_t)
- 2022-06-30
- 2022
- Engelska.
- Ingår i: European Journal of Pediatrics. - : Springer. - 0340-6199 .- 1432-1076. ; 181:8, s. 3119-3129
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- To compare patterns of sedentary (SED) time (more sedentary, SED + vs less sedentary, SED-), moderate to vigorous physical activity (MVPA) time (more active, MVPA + vs less active, MVPA-), and combinations of behaviors (SED-/MVPA + , SED-/MVPA-, SED + /MVPA + , SED + /MVPA-) regarding nonalcoholic fatty liver diseases (NAFLD) markers. This cross-sectional study included 134 subjects (13.4 +/- 2.2 years, body mass index (BMI) 98.9 +/- 0.7 percentile, 48.5% females) who underwent 24-h/7-day accelerometry, anthropometric, and biochemical markers (alanine aminotransferase (ALT) as first criterion, and aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), AST/ALT ratio as secondary criteria). A subgroup of 39 patients underwent magnetic resonance imaging-liver fat content (MRI-LFC). Hepatic health was better in SED- (lower ALT, GGT, and MRI-LFC (p < 0.05), higher AST/ALT (p < 0.01)) vs SED + and in MVPA + (lower ALT (p < 0.05), higher AST/ALT (p < 0.01)) vs MVPA- groups after adjustment for age, gender, and Tanner stages. SED-/MVPA + group had the best hepatic health. SED-/MVPA- group had lower ALT and GGT and higher AST/ALT (p < 0.05) in comparison with SED + /MVPA + group independently of BMI. SED time was positively associated with biochemical (high ALT, low AST/ALT ratio) and imaging (high MRI-LFC) markers independently of MVPA. MVPA time was associated with biochemical markers (low ALT, high AST/ALT) but these associations were no longer significant after adjustment for SED time. Conclusion: Lower SED time is associated with better hepatic health independently of MVPA. Reducing SED time might be a first step in the management of pediatric obesity NAFLD when increasing MVPA is not possible.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Sedentary behavior
- Physical activity
- Pediatric obesity
- Nonalcoholic fatty liver disease
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- ref (ämneskategori)
- art (ämneskategori)
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- Julian, Valerie
- Bergsten, Peter
- Ennequin, Gael
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- Thivel, David
- Weghuber, Daniel
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