SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Rück A)
 

Search: WFRF:(Rück A) > (2001-2004) > Effects of intramyo...

  • Sarkar, N.Karolinska Institutet (author)

Effects of intramyocardial injection of phVEGF-A(165) as sole therapy in patients with refractory coronary artery disease - 12-month follow-up : Angiogenic gene therapy

  • Article/chapterEnglish2001

Publisher, publication year, extent ...

  • Wiley,2001
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-21089
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-21089URI
  • https://doi.org/10.1046/j.1365-2796.2001.00905.xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1935837URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20100525
  • Objective. To test the safety and bioactivity of phVEGF-A(165) after intramyocardial injection during 12-month follow-up. Design. Open-labelled study. Subjects. Inclusion criteria were angina pectoris, Canadian Cardiovascular Society (CCS) class III-IV, unamenable to further revascularization, ejection fraction (EF) >30%, perfusion defects extending over >10% of the anterolateral left ventricle wall detectable with adenosine single photon emission computerized tomography (SPECT) and at least one patent vessel visible by coronary angiography. Seven of 39 patients referred for gene therapy were included. Intervention. Via a mini-thoracotomy under general anaesthesia, phVEGF-A(165) was injected directly into the myocardium at four sites in the anterolateral region of the left ventricle. Results. Operative procedures were uneventful. Perioperative release of myocardial markers and electrocardiogram (ECG) changes were detected in two patients. There were no perioperative deaths but one patient died 7 months postoperatively because of myocardial infarction. Plasma vascular endothelial growth factor (VEGF)-A levels increased two to threefold peaking 6 days postoperatively (P<0.004) and returning to baseline by day 30. A significant reduction in angina pectoris was reported. The CCS class improved from 3.30.2 to 1.9 +/-0.3 (P<0.01) and nitroglycerine intake decreased from 3915 to 12 +/-5 tablets week(-1) (P<0.001) 2 months after gene transfer. Improvements remained after 12 months when nitroglycerine consumption approached zero. Improved myocardial function in the phVEGF-A(165) injection region was documented in all patients (P<0.016) by tissue velocity imaging (TVI). Reduced reversible ischaemia was detected by adenosine SPECT in four patients. Improved collateralization was detected in four patients with coronary angiography. Conclusion. Intramyocardial injection of phVEGF-A(165) is safe and may lead to improved myocardial perfusion and function with longstanding symptomatic relief in end-stage angina pectoris. Based on these results this therapeutic potential is being tested in a double-blind placebo controlled multicentre trial, EUROINJECT ONE.

Subject headings and genre

  • coronary artery disease
  • gene therapy
  • plasmid
  • thoracotomy
  • endothelial growth-factor
  • models
  • vegf

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ruck, A.Karolinska Institutet (author)
  • Kallner, G.Karolinska Institutet (author)
  • Y-Hassan, S.Karolinska Institutet (author)
  • Blomberg, P. (author)
  • Islam, K. B. (author)
  • Van Der Linden, J.Karolinska Institutet (author)
  • Lindblom, D.Karolinska Institutet (author)
  • Nygren, A. T.Karolinska Institutet (author)
  • Lind, B.Karolinska Institutet (author)
  • Brodin, Lars-Åke (author)
  • Drvota, V. (author)
  • Sylven, C.Karolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Journal of Internal Medicine: Wiley250:5, s. 373-3810954-68201365-2796

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view