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Patient-Specific Le...
Patient-Specific Left Ventricular Flow Simulations From Transthoracic Echocardiography : Robustness Evaluation and Validation Against Ultrasound Doppler and Magnetic Resonance Imaging
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- Larsson, David (författare)
- Karolinska Institutet,KTH,Medicinsk bildteknik
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- Spühler, Jeannette Hiromi, 1981- (författare)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST)
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- Petersson, Sven (författare)
- Karolinska Institutet
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- Nordenfur, Tim (författare)
- KTH,Medicinsk bildteknik
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- Colarieti-Tosti, Massimiliano (författare)
- KTH,Medicinsk bildteknik
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- Hoffman, Johan, 1974- (författare)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST)
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- Winter, Reidar (författare)
- Karolinska Institutet
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- Larsson, Matilda, 1981- (författare)
- KTH,Medicinsk bildteknik
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(creator_code:org_t)
- Institute of Electrical and Electronics Engineers (IEEE), 2017
- 2017
- Engelska.
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Ingår i: IEEE Transactions on Medical Imaging. - : Institute of Electrical and Electronics Engineers (IEEE). - 0278-0062 .- 1558-254X. ; 36:11, s. 2261-2275
- Relaterad länk:
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https://doi.org/10.1...
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http://ieeexplore.ie...
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https://kth.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The combination of medical imaging with computational fluid dynamics (CFD) has enabled the study of 3D blood flow on a patient-specificlevel. However, with models based on gated high-resolution data, the study of transient flows, and any model implementation into routine cardiac care, is challenging. The present paper presents a novel pathway for patient-specific CFD modelling of the left ventricle (LV), using 4D transthoracic echocardiography (TTE) as input modality. To evaluate the clinical usability, two sub-studies were performed. First, a robustness evaluation was performed where repeated models with alternating input variables were generated for 6 subjects and changes in simulated output quantified. Second, a validation study was carried out where the pathway accuracy was evaluated against pulsed-wave Doppler (100 subjects), and 2D through-plane phase-contrast magnetic resonance imaging measurements over 7 intraventricular planes (6 subjects). The robustness evaluation indicated a model deviation of <12%, with highest regional and temporal deviations at apical segments and at peak systole, respectively. The validation study showed an error of < 11% (velocities < 10 cm/s) for all subjects, with no significant regional or temporal differences observed. With the patient-specific pathway shown to provide robust output with high accuracy, and with the pathway dependent only on 4DTTE, the method has a high potential to be used within future clinical studies on 3D intraventricular flowpatterns. To this, future model developments in the form of e.g. anatomically accurate LV valves may further enhance the clinical value of the simulations.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Nyckelord
- Medical Technology
- Medicinsk teknologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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