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A subcellular map o...
A subcellular map of the human proteome
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- Thul, Peter J. (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Åkesson, Lovisa (author)
- KTH,Skolan för bioteknologi (BIO),Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Wiking, Mikaela (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Mahdessian, Diana (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Geladaki, A. (author)
- Univ Cambridge, Dept Biochem, Cambridge Ctr Prote, Tennis Court Rd, Cambridge CB2 1QR, England.;Univ Cambridge, Dept Genet, Downing St, Cambridge CB2 3EH, England.
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- Ait Blal, Hammou (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Alm, Tove L. (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Asplund, Anna (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Björk, Lars (author)
- Karolinska Institutet,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Breckels, L. M. (author)
- Univ Cambridge, Dept Biochem, Cambridge Ctr Prote, Tennis Court Rd, Cambridge CB2 1QR, England.;Univ Cambridge, Dept Biochem, Computat Prote Unit, Tennis Court Rd, Cambridge CB2 1QR, England.
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- Bäckström, Anna (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Danielsson, Frida (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Fagerberg, Linn (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Fall, Jenny (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Gatto, L. (author)
- Univ Cambridge, Dept Biochem, Cambridge Ctr Prote, Tennis Court Rd, Cambridge CB2 1QR, England.;Univ Cambridge, Dept Biochem, Computat Prote Unit, Tennis Court Rd, Cambridge CB2 1QR, England.
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- Gnann, Christian (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Hober, Sophia, 1965- (author)
- KTH,Proteinteknologi,KTH Royal Inst Technol, Sch Biotechnol, Dept Prote, SE-10691 Stockholm, Sweden.
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- Hjelmare, Martin (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Johansson, Fredric (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Lee, Sunjae (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Lindskog, Cecilia (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Mulder, J. (author)
- Karolinska Institutet,Karolinska Inst, Dept Neurosci, Sci Life Lab, SE-17177 Stockholm, Sweden.,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Mulvey, C. M. (author)
- Univ Cambridge, Dept Biochem, Cambridge Ctr Prote, Tennis Court Rd, Cambridge CB2 1QR, England.
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- Nilsson, Peter (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Oksvold, Per (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Rockberg, Johan (author)
- KTH,Proteomik och nanobioteknologi,KTH Royal Inst Technol, Sch Biotechnol, Dept Prote, SE-10691 Stockholm, Sweden.
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- Schutten, Rutger (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Schwenk, Jochen M. (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Sivertsson, Åsa (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Sjöstedt, Evelina (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Skogs, Marie, 1981- (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Stadler, Charlotte (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Sullivan, Devin P. (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Tegel, Hanna (author)
- KTH,Proteomik och nanobioteknologi,KTH Royal Inst Technol, Sch Biotechnol, Dept Prote, SE-10691 Stockholm, Sweden.
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- Winsnes, Casper F. (author)
- KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Zhang, Cheng (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Zwahlen, Martin (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Mardinoglu, Adil (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Pontén, Fredrik (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- von Feilitzen, Kalle (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Lilley, K. S. (author)
- Univ Cambridge, Dept Biochem, Cambridge Ctr Prote, Tennis Court Rd, Cambridge CB2 1QR, England.
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Lundberg, Emma (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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(creator_code:org_t)
- American Association for the Advancement of Science, 2017
- 2017
- English.
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In: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 356:6340
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we present a comprehensive image-based map of subcellular protein distribution, the Cell Atlas, built by integrating transcriptomics and antibody-based immunofluorescence microscopy with validation by mass spectrometry. Mapping the in situ localization of 12,003 human proteins at a single-cell level to 30 subcellular structures enabled the definition of the proteomes of 13 major organelles. Exploration of the proteomes revealed single-cell variations in abundance or spatial distribution and localization of about half of the proteins to multiple compartments. This subcellular map can be used to refine existing protein-protein interaction networks and provides an important resource to deconvolute the highly complex architecture of the human cell.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- antibody
- proteome
- biology
- cells and cell components
- disease incidence
- image analysis
- physiological response
- protein
- proteomics
- spatial distribution
- Article
- cell organelle
- cellular distribution
- human
- human cell
- immunofluorescence microscopy
- mass spectrometry
- priority journal
- protein analysis
- protein localization
- protein protein interaction
- single cell analysis
- transcriptomics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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To the university's database
- By the author/editor
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Thul, Peter J.
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Åkesson, Lovisa
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Wiking, Mikaela
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Mahdessian, Dian ...
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Geladaki, A.
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Ait Blal, Hammou
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show more...
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Alm, Tove L.
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Asplund, Anna
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Björk, Lars
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Breckels, L. M.
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Bäckström, Anna
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Danielsson, Frid ...
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Fagerberg, Linn
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Fall, Jenny
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Gatto, L.
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Gnann, Christian
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Hober, Sophia, 1 ...
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Hjelmare, Martin
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Johansson, Fredr ...
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Lee, Sunjae
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Lindskog, Cecili ...
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Mulder, J.
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Mulvey, C. M.
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Nilsson, Peter
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Oksvold, Per
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Rockberg, Johan
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Schutten, Rutger
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Schwenk, Jochen ...
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Sivertsson, Åsa
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Sjöstedt, Evelin ...
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Skogs, Marie, 19 ...
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Stadler, Charlot ...
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Sullivan, Devin ...
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Tegel, Hanna
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Winsnes, Casper ...
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Zhang, Cheng
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Zwahlen, Martin
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Mardinoglu, Adil
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Pontén, Fredrik
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von Feilitzen, K ...
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Lilley, K. S.
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Uhlén, Mathias
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Lundberg, Emma
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Science
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University
