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Sensitivity to inte...
Abstract
Ämnesord
Stäng
- Pairing specific LTD (PSD) is produced by paired parallel fiber (PF) and climbing fiber (CF) stimulation and requires Ca2+ elevation. CF or PF activation cause Ca2+ increase through voltage dependent channels and IP3 induced Ca2+ release, respectively. We developed a model of Ca2+ dynamics in Purkinje cell spines to investigate why paired PF-CF activation is necessary for PSD. Simulations show a supralinear increase of the Ca2+ signal if the CF input occurs in a restricted time interval following the PF input. Ca2- buffers significantly contribute to this phenomenon. This mechanism may be involved in the requirement of temporal specificity in classical conditioning.
Nyckelord
- classical conditioning
- Purkinje cells
- IP3 induced Ca2+ release
- Ca2+ buffers
- LTD
- long-term depression
- neurons
- ca2
- insp(3)
- release
- rabbit
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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