A supramolecular peptide polymer from hydrogen-bond and coordination-driven self-assembly

• A terpyridine- and guanine-functionalized peptide was developed that could form different morphologies by self-assembly or coordination with Fe2+ in dimethyl sulfoxide. The self-assembly of the peptide is attributed to the G-quartet formation of a guanine moiety and intermolecular terpyridine π-π stacking. Upon the addition of Fe2+, a Fe2+-(terpyridine)2 complex is formed that turns the square-planar self-assembly to a three-dimensional self-assembly. As a consequence, a variety of interesting morphologies and chemical properties were observed. The self-assembled polymers were studied by nuclear magnetic resonance spectroscopy, ultraviolet-visible and fluorescence spectroscopy, viscosity measurement, circular dichroism, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, dynamic light scattering, and atomic force microscopy. This external stimuli driven self-assembly of a peptide may be further applied to drug delivery applications. 

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Atomic force microscopy

Circular dichroism spectroscopy

Dichroism

Dimethyl sulfoxide

Electron microscopy

Fluorescence spectroscopy

Fourier transform infrared spectroscopy

High resolution transmission electron microscopy

Hydrogen bonds

Light scattering

Magnetic resonance spectroscopy

Nuclear magnetic resonance spectroscopy

Peptides

Polymers

Positive ions

Scanning electron microscopy

Transmission electron microscopy

Viscosity measurement

X ray diffraction

Coordination-driven self assembly

Drug delivery applications

External stimulus

Functionalized

Guanine moiety

Pi-stacking

Scanning electrons

Terpyridines

Self assembly

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)