Neutrophil Elastase-Derived Fibrin Degradation Products Indicate Presence of Abdominal Aortic Aneurysms and Correlate with Intraluminal Thrombus Volume

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Liljeqvist, Moritz LindquistKarolinska Institutet (author)

Neutrophil Elastase-Derived Fibrin Degradation Products Indicate Presence of Abdominal Aortic Aneurysms and Correlate with Intraluminal Thrombus Volume

Article/chapterEnglish2018

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Schattauer GmbH Verlag für Medizin und Naturwissenschaften,2018
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LIBRIS-ID:oai:DiVA.org:kth-223278
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-223278URI
https://doi.org/10.1160/TH17-05-0348DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:137548429URI

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Language:English
Summary in:English

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QC 20180216
Background The intraluminal thrombi (ILT) of abdominal aortic aneurysms (AAA) contain neutrophils, which can secrete elastase. We evaluated whether plasma neutrophil elastase-derived cross-linked fibrin degradation products (E-XDP) could reveal the presence, size and mechanical stress of AAAs and its ILTs. Methods E-XDP and D-dimer were measured in plasma from 37 male patients with AAA and 42 male controls. The ILT volumes of the AAAs and any coexisting aneurysms could be measured in 29 patients and finite element analysis was performed to estimate mechanical stress of the ILT. E-XDP, neutrophil elastase and neutrophil marker CD66acd were evaluated in aortic tissue with immunohistochemistry (IHC). The association between ILT volume and E-XDP was validated in a separate cohort (n = 51). Results E-XDP levels were elevated in patients with AAA compared with controls (p = 5.8e-13), indicated AAA with 98% sensitivity, 86% specificity and increased with presence of coexisting aneurysms. The association between AAA and increased E-XDP was independent of smoking, comorbidities and medication. E-XDP correlated with volume of all ILTs (r = 0.76, p = 4.5e-06), mean ILTstress (r = 0.46, p = 0.013) and the volume of the AAA-associated ILT (r = 0.64, p = 0.00017). E-XDP correlated stronger with ILT volume compared with D-dimer (r = 0.76 vs. r = 0.64, p = 0.018). The correlation between E-XDP and ILT volume was validated in the separate cohort (r = 0.53, p = 7.6e-05). IHC revealed E-XDP expression in the ILT, spatially related to neutrophil elastase and neutrophils. Conclusion E-XDP is a marker of the presence of AAA and coexisting aneurysms as well as the volume and mechanical stress of the ILT.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
thrombus
leukocyte elastase
aortic aneurysm
abdominal
finite element analysis
computed tomography

Added entries (persons, corporate bodies, meetings, titles ...)

Silveira, AngelaKarolinska Institutet (author)
Hultgren, RebeckaKarolinska Institutet (author)
Frebelius, SiwKarolinska Institutet (author)
Lengquist, Mariette (author)
Engström, Jan (author)
Gasser, ChristianKTH,Hållfasthetslära (Inst.)(Swepub:kth)u1dvxi4s (author)
Eriksson, PerKarolinska Institutet (author)
Roy, JoyKarolinska Institutet (author)
Karolinska InstitutetHållfasthetslära (Inst.) (creator_code:org_t)

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In:Thrombosis and Haemostasis: Schattauer GmbH Verlag für Medizin und Naturwissenschaften118:2, s. 329-3390340-62452567-689X

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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By the university: Royal Institute of Technology; Karolinska Institutet

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